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Science 299 (5604): 214-215

Copyright © 2003 by the American Association for the Advancement of Science

APOPTOSIS:
Life and Death Decisions

Donald W. Nicholson and Nancy A. Thornberry

Screening small molecules for their ability to perturb a cellular pathway, a strategy called forward chemical genetics, can yield unexpected information about other pathway components. This is well illustrated by new work (Jiang et al.), as Nicholson and Thornberry discuss in their Perspective. Discovery of a small-molecule activator of apoptosis implicated a tumor suppressor protein and an oncoprotein in the regulation of the mitochondrial cell death pathway.

D. W. Nicholson is at the Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Montreal, Quebec HLH 3LI, Canada. N. A. Thornberry is at Merck Research Laboratories, Rahway, NJ 07065, USA. E-mail: nancy_thornberry{at}merck.com

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