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Science 299 (5605): 355-356

Copyright © 2003 by the American Association for the Advancement of Science

What Makes an Embryo Stick?

Asgerally T. Fazleabas and J. Julie Kim

Implantation of the human embryo into the uterine lining is a crucial step during early pregnancy, yet little is known about the molecular mechanisms involved. In their Perspective, Fazleabas and Kim discuss new work (Genbacev et al.) identifying L-selectin expressed by trophoblast cells of the blastocyst as a crucial mediator of the initial interaction between the embryo and uterine lining, the first step in implantation.

The authors are in the Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL 60612, USA. E-mail: asgi{at}

Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis.
J. J. Brosens, A. Hodgetts, F. Feroze-Zaidi, J. R. A. Sherwin, L. Fusi, M. S. Salker, J. Higham, G. L. Rose, T. Kajihara, S. L. Young, et al. (2010)
Mol. Hum. Reprod. 16, 273-285
   Abstract »    Full Text »    PDF »
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment.
M. S. M. van Mourik, N. S. Macklon, and C. J. Heijnen (2009)
J. Leukoc. Biol. 85, 4-19
   Abstract »    Full Text »    PDF »
Endometrial receptivity markers, the journey to successful embryo implantation.
H. Achache and A. Revel (2006)
Hum. Reprod. Update 12, 731-746
   Abstract »    Full Text »    PDF »

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