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Implantation of the human embryo into the uterine lining is a crucial step during early pregnancy, yet little is known about the molecular mechanisms involved. In their Perspective, Fazleabas and Kim discuss new work (Genbacevet al.) identifying L-selectin expressed by trophoblast cells of the blastocyst as a crucial mediator of the initial interaction between the embryo and uterine lining, the first step in implantation.
The authors are in the Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL 60612, USA. E-mail: asgi{at}uic.edu
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In Science Magazine
REPORTS
Olga D. Genbacev, Akraporn Prakobphol, Russell A. Foulk, Ana R. Krtolica, Dusko Ilic, Mark S. Singer, Zhi-Qiang Yang, Laura L. Kiessling, Steven D. Rosen, and Susan J. Fisher (17 January 2003) Science299 (5605), 405.
[DOI: 10.1126/science.1079546] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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