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Science 299 (5608): 835-837

Copyright © 2003 by the American Association for the Advancement of Science

Love, Honor, and Protect (Your Liver)

Alan J. Davidson and Leonard I. Zon

The liver has remarkable powers of regeneration, and can regrow to its original size even after 70% of its mass has been surgically removed. In a Perspective, Davidson and Zon reveal part of the liver's secret of success. As reported by LeCouter et al., liver injury induces the secretion of VEGF-A, which then directs liver endothelial cells to secrete growth and survival factors that in turn promote hepatocyte proliferation and survival.

The authors are in the Department of Medicine, Division of Hematology/Oncology, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. E-mail: zon{at}

Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model.
R. Jindal, Y. Nahmias, A. W. Tilles, F. Berthiaume, and M. L. Yarmush (2009)
FASEB J 23, 2288-2298
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity.
B. Donahower, S. S. McCullough, R. Kurten, L. W. Lamps, P. Simpson, J. A. Hinson, and L. P. James (2006)
Am J Physiol Gastrointest Liver Physiol 291, G102-G109
   Abstract »    Full Text »    PDF »

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