Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
BIOMEDICINE: Love, Honor, and Protect (Your Liver)
Alan J. Davidson and Leonard I. Zon
The liver has remarkable powers of regeneration, and can regrow to its original size even after 70% of its mass has been surgically removed. In a Perspective, Davidson and Zon reveal part of the liver's secret of success. As reported by LeCouter et al., liver injury induces the secretion of VEGF-A, which then directs liver endothelial cells to secrete growth and survival factors that in turn promote hepatocyte proliferation and survival.
The authors are in the Department of Medicine, Division of Hematology/Oncology, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. E-mail: zon{at}hhmi.tchlab.org
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Jennifer LeCouter, Dirk R. Moritz, Bing Li, Gail Lewis Phillips, Xiao Huan Liang, Hans-Peter Gerber, Kenneth J. Hillan, and Napoleone Ferrara (7 February 2003) Science299 (5608), 890.
[DOI: 10.1126/science.1079562] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model.
R. Jindal, Y. Nahmias, A. W. Tilles, F. Berthiaume, and M. L. Yarmush (2009)
FASEB J
23, 2288-2298
|Abstract »|Full Text »|PDF »
Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity.
B. Donahower, S. S. McCullough, R. Kurten, L. W. Lamps, P. Simpson, J. A. Hinson, and L. P. James (2006)
Am J Physiol Gastrointest Liver Physiol
291, G102-G109
|Abstract »|Full Text »|PDF »
