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Science 299 (5608): 838-839

Copyright © 2003 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: NO Says Yes to Mitochondria

Guy C. Brown

What boosts the number of mitochondria in our cells when, for example, we need to generate more heat or to work our muscles harder? In his Perspective, Brown discusses the answer to this question revealed in new work by Nisoli and colleagues. The gas nitric oxide (produced by endothelial nitric oxide synthase) activates a transcriptional coactivator that directs expression of genes, which induce mitochondrial biogenesis.

The author is in the Department of Biochemistry, Cambridge University, Cambridge CB2 1QW, UK. E-mail: gcb{at}

The Hepatitis E Virus Orf3 Protein Protects Cells from Mitochondrial Depolarization and Death.
S. M. Moin, M. Panteva, and S. Jameel (2007)
J. Biol. Chem. 282, 21124-21133
   Abstract »    Full Text »    PDF »
Mechanisms for nitric oxide synthesis in plants.
N. M. Crawford (2006)
J. Exp. Bot. 57, 471-478
   Abstract »    Full Text »    PDF »
Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced Senescence.
F.-Q. Guo and N. M. Crawford (2005)
PLANT CELL 17, 3436-3450
   Abstract »    Full Text »    PDF »
Model Systems for Environmental Signaling.
N. W. Blackstone and D. M. Bridge (2005)
Integr. Comp. Biol. 45, 605-614
   Abstract »    Full Text »    PDF »
Effect of sustained hypobaric hypoxia during maturation and aging on rat myocardium. I. Mechanical activity.
P. La Padula and L. E. Costa (2005)
J Appl Physiol 98, 2363-2369
   Abstract »    Full Text »    PDF »
Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging.
A. Navarro and A. Boveris (2004)
Am J Physiol Regulatory Integrative Comp Physiol 287, R1244-R1249
   Abstract »    Full Text »    PDF »

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