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Science 299 (5609): 1025-1027

Copyright © 2003 by the American Association for the Advancement of Science

SIGNAL TRANSDUCTION:
Imposing Specificity on Kinases

Mark Ptashne and Alexander Gann

How does a cell imbue kinase signaling cascades that share some of the same components with a specificity that ensures activation of the correct cellular response? In their Perspective, Ptashne and Gann discuss the leading part played by protein scaffolds and regulated recruitment in conferring specificity on kinase signaling cascades.


M. Ptashne is in the Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: m-ptashne{at}ski.mskcc.org A. Gann is at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. E-mail: ganna{at}csh.org


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Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
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P. M. Gilmore, N. McCabe, J. E. Quinn, R. D. Kennedy, J. J. Gorski, H. N. Andrews, S. McWilliams, M. Carty, P. B. Mullan, W. P. Duprex, et al. (2004)
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