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Science 299 (5609): 1030-1031

Copyright © 2003 by the American Association for the Advancement of Science

IMMUNOLOGY:
Regulating the Regulators

Fiona Powrie and Kevin J. Maloy

Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (TR) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology (Hori et al., Pasare and Medzhitov).

The authors are at the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. E-mail: fiona.powrie{at}path. ox.ac.uk

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