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Science 299 (5609): 1030-1031

Copyright © 2003 by the American Association for the Advancement of Science

Regulating the Regulators

Fiona Powrie and Kevin J. Maloy

Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (TR) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology (Hori et al., Pasare and Medzhitov).

The authors are at the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. E-mail: fiona.powrie{at}path.

Telling apart friend from foe: discriminating between commensals and pathogens at mucosal sites.
N. Srinivasan (2010)
Innate Immunity 16, 391-404
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TGF-{beta} and 'Adaptive' Foxp3+ Regulatory T cells.
W. Chen and J. E. Konkel (2010)
J Mol Cell Biol 2, 30-36
   Abstract »    Full Text »    PDF »
Roles for Inflammation and Regulatory T Cells in Colon Cancer.
S. E. Erdman and T. Poutahidis (2010)
Toxicol Pathol 38, 76-87
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Nitric oxide and TNF-{alpha} trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice.
S. E. Erdman, V. P. Rao, T. Poutahidis, A. B. Rogers, C. L. Taylor, E. A. Jackson, Z. Ge, C. W. Lee, D. B. Schauer, G. N. Wogan, et al. (2009)
PNAS 106, 1027-1032
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Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection.
H. Ebinuma, N. Nakamoto, Y. Li, D. A. Price, E. Gostick, B. L. Levine, J. Tobias, W. W. Kwok, and K.-M. Chang (2008)
J. Virol. 82, 5043-5053
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Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
T. Poutahidis, K. M. Haigis, V. P. Rao, P. R. Nambiar, C. L. Taylor, Z. Ge, K. Watanabe, A. Davidson, B. H. Horwitz, J. G. Fox, et al. (2007)
Carcinogenesis 28, 2614-2623
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Functional Foxp3+ CD4+ CD25(Bright+) "Natural" Regulatory T Cells Are Abundant in Rabbit Conjunctiva and Suppress Virus-Specific CD4+ and CD8+ Effector T Cells during Ocular Herpes Infection.
A. B. Nesburn, I. Bettahi, G. Dasgupta, A. A. Chentoufi, X. Zhang, S. You, N. Morishige, A. J. Wahlert, D. J. Brown, J. V. Jester, et al. (2007)
J. Virol. 81, 7647-7661
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Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individuals.
A. Kinter, J. McNally, L. Riggin, R. Jackson, G. Roby, and A. S. Fauci (2007)
PNAS 104, 3390-3395
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FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells.
C. Daniel, N. Sartory, N. Zahn, G. Geisslinger, H. H. Radeke, and J. M. Stein (2007)
J. Immunol. 178, 2458-2468
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Breast Cancer: Should Gastrointestinal Bacteria Be on Our Radar Screen?.
V. P. Rao, T. Poutahidis, J. G. Fox, and S. E. Erdman (2007)
Cancer Res. 67, 847-850
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CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells..
P. Ancuta, J. Wang, and D. Gabuzda (2006)
J. Leukoc. Biol. 80, 1156-1164
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Transforming growth factor {beta} induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.
M C Fantini, C Becker, I Tubbe, A Nikolaev, H A Lehr, P Galle, and M F Neurath (2006)
Gut 55, 671-680
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Frequency of Natural Regulatory CD4+CD25+ T Lymphocytes Determines the Outcome of Tolerance across Fully Mismatched MHC Barrier through Linked Recognition of Self and Allogeneic Stimuli.
R. Fucs, J. T. Jesus, P. H. N. Souza Junior, L. Franco, M. Vericimo, M. Bellio, and A. Nobrega (2006)
J. Immunol. 176, 2324-2329
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Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
B. Ruiz-Perez, D. R. Chung, A. H. Sharpe, H. Yagita, W. M. Kalka-Moll, M. H. Sayegh, D. L. Kasper, and A. O. Tzianabos (2005)
PNAS 102, 16753-16758
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Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function.
G. Peng, Z. Guo, Y. Kiniwa, K. s. Voo, W. Peng, T. Fu, D. Y. Wang, Y. Li, H. Y. Wang, and R.-F. Wang (2005)
Science 309, 1380-1384
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Cutting Edge: IL-12 Induces CD4+CD25- T Cell Activation in the Presence of T Regulatory Cells.
I. L. King and B. M. Segal (2005)
J. Immunol. 175, 641-645
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CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice.
S. E. Erdman, J. J. Sohn, V. P. Rao, P. R. Nambiar, Z. Ge, J. G. Fox, and D. B. Schauer (2005)
Cancer Res. 65, 3998-4004
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Quantitating Effector and Regulatory T Lymphocytes in Immune Responses by Limiting Dilution Analysis Modeling.
T. Bonnefoix, P. Bonnefoix, P. Perron, J.-Q. Mi, W. F. Ng, R. Lechler, J.-C. Bensa, J.-Y. Cahn, and D. Leroux (2005)
J. Immunol. 174, 3421-3431
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Functional Characterization of EBV-Encoded Nuclear Antigen 1-Specific CD4+ Helper and Regulatory T Cells Elicited by In vitro Peptide Stimulation.
K. S. Voo, G. Peng, Z. Guo, T. Fu, Y. Li, L. Frappier, and R.-F. Wang (2005)
Cancer Res. 65, 1577-1586
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Characterization of a B220+ Lymphoid Cell Subpopulation with Immune Modulatory Functions in Nasal-Associated Lymphoid Tissues.
F. Rharbaoui, D. Bruder, M. Vidakovic, T. Ebensen, J. Buer, and C. A. Guzman (2005)
J. Immunol. 174, 1317-1324
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Macrophages Expressing Triggering Receptor Expressed on Myeloid Cells-1 Are Underrepresented in the Human Intestine.
M. Schenk, A. Bouchon, S. Birrer, M. Colonna, and C. Mueller (2005)
J. Immunol. 174, 517-524
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A Critical Regulatory Role of Leucin Zipper Transcription Factor c-Maf in Th1-Mediated Experimental Colitis.
B. Weigmann, A. Nemetz, C. Becker, J. Schmidt, D. Strand, H. A. Lehr, P. R. Galle, I.- C. Ho, and M. F. Neurath (2004)
J. Immunol. 173, 3446-3455
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Activation and Proteasomal Degradation of Rho GTPases by Cytotoxic Necrotizing Factor-1 Elicit a Controlled Inflammatory Response.
P. Munro, G. Flatau, A. Doye, L. Boyer, O. Oregioni, J.-L. Mege, L. Landraud, and E. Lemichez (2004)
J. Biol. Chem. 279, 35849-35857
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CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status.
A. L. Kinter, M. Hennessey, A. Bell, S. Kern, Y. Lin, M. Daucher, M. Planta, M. McGlaughlin, R. Jackson, S. F. Ziegler, et al. (2004)
J. Exp. Med. 200, 331-343
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Influence of normal microbiota on some aspects of the immune response during experimental infection with Trypanosoma cruzi in mice.
R. Duarte, A. M. Silva, L. Q. Vieira, L. C. C. Afonso, and J. R. Nicoli (2004)
J. Med. Microbiol. 53, 741-748
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TGF-{beta}: the perpetrator of immune suppression by regulatory T cells and suicidal T cells.
S. M. Wahl, J. Swisher, N. McCartney-Francis, and W. Chen (2004)
J. Leukoc. Biol. 76, 15-24
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Timed Ablation of Regulatory CD4+ T Cells Can Prevent Murine AIDS Progression.
M. W. Beilharz, L. M. Sammels, A. Paun, K. Shaw, P. van Eeden, M. W. Watson, and M. L. Ashdown (2004)
J. Immunol. 172, 4917-4925
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Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis.
A. B. Stavitsky (2004)
Infect. Immun. 72, 1-12
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CD4+CD25+ Regulatory Lymphocytes Require Interleukin 10 to Interrupt Colon Carcinogenesis in Mice.
S. E. Erdman, V. P. Rao, T. Poutahidis, M. M. Ihrig, Z. Ge, Y. Feng, M. Tomczak, A. B. Rogers, B. H. Horwitz, and J. G. Fox (2003)
Cancer Res. 63, 6042-6050
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