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Science 300 (5619): 592-594

Copyright © 2003 by the American Association for the Advancement of Science

BIOCHEMISTRY:
An Overoxidation Journey with a Return Ticket

George Georgiou and Lluis Masip

The peroxiredoxins are ubiquitous enzymes that catalyze the reduction of hydrogen peroxide. In their Perspective, Georgiou and Masip discuss some intriguing new details of peroxiredoxin biochemistry that reveal how these enzymes can be simultaneously both antioxidants and modulators of signal transduction (Wood et al.; Woo et al.).

The authors are in the Department of Chemical Engineering, Biomedical Engineering and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. E-mail: gg{at}che.utexas.edu

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