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Science 300 (5619): 592-594

Copyright © 2003 by the American Association for the Advancement of Science

An Overoxidation Journey with a Return Ticket

George Georgiou and Lluis Masip

The peroxiredoxins are ubiquitous enzymes that catalyze the reduction of hydrogen peroxide. In their Perspective, Georgiou and Masip discuss some intriguing new details of peroxiredoxin biochemistry that reveal how these enzymes can be simultaneously both antioxidants and modulators of signal transduction (Wood et al.; Woo et al.).

The authors are in the Department of Chemical Engineering, Biomedical Engineering and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. E-mail: gg{at}

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Glycobiology 24, 428-441
   Abstract »    Full Text »    PDF »
Crystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with {alpha}-Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for Catalysis.
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J. Bacteriol. 194, 6206-6216
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Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte.
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Plant Physiology 141, 312-322
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Integr. Comp. Biol. 45, 605-614
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Science 304, 596-600
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