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Transmembrane proteins called integrins regulate cell adhesion by interacting with both external ligands and internal cytoskeletal proteins. In his Perspective, Hynes explores the molecular changes in the different segments of integrins that contribute to integrin activation and cell adhesion (Li et al.).
The author is a Howard Hughes Medical Institute Investigator at the Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: rohynes{at}mit.edu
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In Science Magazine
REPORTS
Renhao Li, Neal Mitra, Holly Gratkowski, Gaston Vilaire, Rustem Litvinov, Chandrasekaran Nagasami, John W. Weisel, James D. Lear, William F. DeGrado, and Joel S. Bennett (2 May 2003) Science300 (5620), 795.
[DOI: 10.1126/science.1079441] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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R. Carreno, W. S. Brown, D. Li, J. A. Hernandez, Y. Wang, T. K. Kim, J. W. Craft Jr, K. V. Komanduri, L. G. Radvanyi, P. Hwu, et al. (2010)
J. Biol. Chem.
285, 32860-32868
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LFA-1 Regulates CD8+ T Cell Activation via T Cell Receptor-mediated and LFA-1-mediated Erk1/2 Signal Pathways.
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Y. Wang, D. Li, R. Nurieva, J. Yang, M. Sen, R. Carreno, S. Lu, B. W. McIntyre, J. J. Molldrem, G. B. Legge, et al. (2009)
J. Biol. Chem.
284, 12645-12653
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Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability.
I. N. Gavrilovskaya, E. E. Gorbunova, N. A. Mackow, and E. R. Mackow (2008)
J. Virol.
82, 5797-5806
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Specific Amino Acid Dependency Regulates the Cellular Behavior of Melanoma.
The Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin {beta}2 Subunit at 1.8-A Resolution.
M. Shi, K. Sundramurthy, B. Liu, S.-M. Tan, S. K. A. Law, and J. Lescar (2005)
J. Biol. Chem.
280, 30586-30593
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The {beta}3 subunit of the integrin {alpha}IIb{beta}3 regulates {alpha}IIb-mediated outside-in signaling.
J. Liu, C. W. Jackson, R. A. Gruppo, L. K. Jennings, and T. K. Gartner (2005)
Blood
105, 4345-4352
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Transmembrane Domain Helix Packing Stabilizes Integrin {alpha}IIb{beta}3 in the Low Affinity State.
A. W. Partridge, S. Liu, S. Kim, J. U. Bowie, and M. H. Ginsberg (2005)
J. Biol. Chem.
280, 7294-7300
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Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent {alpha}v{beta}3 integrin conformers.
T. Raymond, E. Gorbunova, I. N. Gavrilovskaya, and E. R. Mackow (2005)
PNAS
102, 1163-1168
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