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Science 300 (5620): 755-756

Copyright © 2003 by the American Association for the Advancement of Science

Changing Partners

Richard O. Hynes

Transmembrane proteins called integrins regulate cell adhesion by interacting with both external ligands and internal cytoskeletal proteins. In his Perspective, Hynes explores the molecular changes in the different segments of integrins that contribute to integrin activation and cell adhesion (Li et al.).

The author is a Howard Hughes Medical Institute Investigator at the Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: rohynes{at}

2E8 Binds to the High Affinity I-domain in a Metal Ion-dependent Manner: A SECOND GENERATION MONOCLONAL ANTIBODY SELECTIVELY TARGETING ACTIVATED LFA-1.
R. Carreno, W. S. Brown, D. Li, J. A. Hernandez, Y. Wang, T. K. Kim, J. W. Craft Jr, K. V. Komanduri, L. G. Radvanyi, P. Hwu, et al. (2010)
J. Biol. Chem. 285, 32860-32868
   Abstract »    Full Text »    PDF »
LFA-1 Regulates CD8+ T Cell Activation via T Cell Receptor-mediated and LFA-1-mediated Erk1/2 Signal Pathways.
D. Li, J. J. Molldrem, and Q. Ma (2009)
J. Biol. Chem. 284, 21001-21010
   Abstract »    Full Text »    PDF »
LFA-1 Affinity Regulation Is Necessary for the Activation and Proliferation of Naive T Cells.
Y. Wang, D. Li, R. Nurieva, J. Yang, M. Sen, R. Carreno, S. Lu, B. W. McIntyre, J. J. Molldrem, G. B. Legge, et al. (2009)
J. Biol. Chem. 284, 12645-12653
   Abstract »    Full Text »    PDF »
Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability.
I. N. Gavrilovskaya, E. E. Gorbunova, N. A. Mackow, and E. R. Mackow (2008)
J. Virol. 82, 5797-5806
   Abstract »    Full Text »    PDF »
Specific Amino Acid Dependency Regulates the Cellular Behavior of Melanoma.
Y.-M. Fu and G. G. Meadows (2007)
J. Nutr. 137, 1591S-1596S
   Abstract »    Full Text »    PDF »
The Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin {beta}2 Subunit at 1.8-A Resolution.
M. Shi, K. Sundramurthy, B. Liu, S.-M. Tan, S. K. A. Law, and J. Lescar (2005)
J. Biol. Chem. 280, 30586-30593
   Abstract »    Full Text »    PDF »
The {beta}3 subunit of the integrin {alpha}IIb{beta}3 regulates {alpha}IIb-mediated outside-in signaling.
J. Liu, C. W. Jackson, R. A. Gruppo, L. K. Jennings, and T. K. Gartner (2005)
Blood 105, 4345-4352
   Abstract »    Full Text »    PDF »
Transmembrane Domain Helix Packing Stabilizes Integrin {alpha}IIb{beta}3 in the Low Affinity State.
A. W. Partridge, S. Liu, S. Kim, J. U. Bowie, and M. H. Ginsberg (2005)
J. Biol. Chem. 280, 7294-7300
   Abstract »    Full Text »    PDF »
Pathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent {alpha}v{beta}3 integrin conformers.
T. Raymond, E. Gorbunova, I. N. Gavrilovskaya, and E. R. Mackow (2005)
PNAS 102, 1163-1168
   Abstract »    Full Text »    PDF »

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