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Science 300 (5625): 1512-1513

Copyright © 2003 by the American Association for the Advancement of Science

Beginning at the End

Antony M. Carr

An essential element of cell survival is the ability to respond to DNA damage. In his Perspective, Carr discusses new findings that reveal the molecular underpinnings of one of the checkpoint pathways that recognizes DNA damage and arrest of DNA replication. This pathway is activated by checkpoint proteins binding to single-stranded DNA that is bound to the RPA protein (Zou and Elledge).

The author is at the Genome Damage and Stability Centre, University of Sussex, Falmer, Sussex BN1 9RQ, UK. E-mail: a.m.carr{at}

Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.
N. Grandin and M. Charbonneau (2007)
Nucleic Acids Res. 35, 822-838
   Abstract »    Full Text »    PDF »
Involvement of KU80 in T-DNA integration in plant cells.
J. Li, M. Vaidya, C. White, A. Vainstein, V. Citovsky, and T. Tzfira (2005)
PNAS 102, 19231-19236
   Abstract »    Full Text »    PDF »
Interaction of Checkpoint Proteins Hus1/Rad1/Rad9 with DNA Base Excision Repair Enzyme MutY Homolog in Fission Yeast, Schizosaccharomyces pombe.
D.-Y. Chang and A-L. Lu (2005)
J. Biol. Chem. 280, 408-417
   Abstract »    Full Text »    PDF »
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.
K. Furuya, M. Poitelea, L. Guo, T. Caspari, and A. M. Carr (2004)
Genes & Dev. 18, 1154-1164
   Abstract »    Full Text »    PDF »
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.
N. R. den Elzen and M. J. O'Connell (2004)
EMBO J. 23, 908-918
   Abstract »    Full Text »    PDF »
Mec1 and Rad53 Inhibit Formation of Single-Stranded DNA at Telomeres of Saccharomyces cerevisiae cdc13-1 Mutants.
X. Jia, T. Weinert, and D. Lydall (2004)
Genetics 166, 753-764
   Abstract »    Full Text »    PDF »
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.
D. Lydall (2003)
J. Cell Sci. 116, 4057-4065
   Abstract »    Full Text »    PDF »

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