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Science 301 (5631): 319-320

Copyright © 2003 by the American Association for the Advancement of Science

Clocks on the Brain

Carla B. Green and Michael Menaker

In many animals, circadian oscillators in the brain and periphery synchronize gene expression and behavior with the 24-hour day:night cycle. In their Perspective, Green and Menaker discuss new work (Dudley et al.), which shows that the master oscillator in the hypothalamus, the suprachiasmatic nucleus, cooperates with an oscillator in the forebrain to synchronize circadian behavior in mice.

The authors are in the Department of Biology and Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA.

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.
N. Nader, G. P. Chrousos, and T. Kino (2009)
FASEB J 23, 1572-1583
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Imbalance of Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder.
B. Mitterauer (2004)
Neuroscientist 10, 199-206
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