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In many animals, circadian oscillators in the brain and periphery synchronize gene expression and behavior with the 24-hour day:night cycle. In their Perspective, Green and Menaker discuss new work (Dudley et al.), which shows that the master oscillator in the hypothalamus, the suprachiasmatic nucleus, cooperates with an oscillator in the forebrain to synchronize circadian behavior in mice.
The authors are in the Department of Biology and Center for Biological Timing, University of Virginia, Charlottesville, VA 22904, USA.
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In Science Magazine
REPORTS
Carol A. Dudley, Claudia Erbel-Sieler, Sandi Jo Estill, Martin Reick, Paul Franken, SiNae Pitts, and Steven L. McKnight (18 July 2003) Science301 (5631), 379.
[DOI: 10.1126/science.1082795] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.
