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Science 301 (5634): 774-776

Copyright © 2003 by the American Association for the Advancement of Science

Longing for Ligand: Hedgehog, Patched, and Cell Death

Isabel Guerrero and Ariel Ruiz i Altaba

The hedgehog signaling pathway controls crucial events during development. In a Perspective, Guerrero and Ruiz i Altaba discuss new work (Thibert et al.) that identifies the Ptc1 receptor for Sonic hedgehog as a crucial modulator of programmed cell death during development of the chick neural tube. Ptc1 joins a cadre of other receptors, called ligand dependence receptors, that induce the programmed cell death of cells bearing them if they remain unoccupied by ligand.

I. Guerrero is in the Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Universidad Autónoma de Madrid, Madrid E-28049, Spain. E-mail: iguerrero{at} A. Ruiz i Altaba is in the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. E-mail: ria{at}

Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation.
R. C. Moraes, H. Chang, N. Harrington, J. D. Landua, J. T. Prigge, T. F. Lane, B. J. Wainwright, P. A. Hamel, and M. T. Lewis (2009)
Development 136, 1423-1432
   Abstract »    Full Text »    PDF »
Neural Influences on Sonic Hedgehog and Apoptosis in the Rat Penis.
C. Bond, Y. Tang, and C. A. Podlasek (2008)
Biol Reprod 78, 947-956
   Abstract »    Full Text »    PDF »
Regulation of ventral midbrain patterning by Hedgehog signaling.
R. D. Bayly, M. Ngo, G. V. Aglyamova, and S. Agarwala (2007)
Development 134, 2115-2124
   Abstract »    Full Text »    PDF »
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia.
R. C. Moraes, X. Zhang, N. Harrington, J. Y. Fung, M.-F. Wu, S. G. Hilsenbeck, D. C. Allred, and M. T. Lewis (2007)
Development 134, 1231-1242
   Abstract »    Full Text »    PDF »
Regulation of Cavernous Nerve Injury-Induced Apoptosis by Sonic Hedgehog.
C. A. Podlasek, C. L. Meroz, Y. Tang, K. E. McKenna, and K. T. McVary (2007)
Biol Reprod 76, 19-28
   Abstract »    Full Text »    PDF »
Sonic Hedgehog and Bone Morphogenetic Protein Regulate Interneuron Development from Dorsal Telencephalic Progenitors In Vitro.
A. Gulacsi and L. Lillien (2003)
J. Neurosci. 23, 9862-9872
   Abstract »    Full Text »    PDF »

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