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Science 301 (5634): 774-776

Copyright © 2003 by the American Association for the Advancement of Science

DEVELOPMENT:
Longing for Ligand: Hedgehog, Patched, and Cell Death

Isabel Guerrero and Ariel Ruiz i Altaba

The hedgehog signaling pathway controls crucial events during development. In a Perspective, Guerrero and Ruiz i Altaba discuss new work (Thibert et al.) that identifies the Ptc1 receptor for Sonic hedgehog as a crucial modulator of programmed cell death during development of the chick neural tube. Ptc1 joins a cadre of other receptors, called ligand dependence receptors, that induce the programmed cell death of cells bearing them if they remain unoccupied by ligand.

I. Guerrero is in the Centro de Biología Molecular "Severo Ochoa," CSIC-UAM, Universidad Autónoma de Madrid, Madrid E-28049, Spain. E-mail: iguerrero{at}cbm.uam.es A. Ruiz i Altaba is in the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. E-mail: ria{at}saturn.med.nyu.edu

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