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Science 301 (5638): 1334-1335

Copyright © 2003 by the American Association for the Advancement of Science

Hide and Seek in the Peptidome

Jonathan W. Yewdell

T cells of the adaptive immune system detect foreign pathogens by recognizing pathogen-derived peptides in a complex with MHC class I molecules presented on the surface of infected cells. In a Perspective, Yewdell discusses progress in understanding how cells generate peptides from cellular and viral proteins and the wily ways in which the Epstein Barr virus conceals its peptide products from the host immune system (Schwab et al., Yin et al.).

The author is at the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA. E-mail: jyewdell{at}

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.
L. C. Anton and J. W. Yewdell (2014)
J. Leukoc. Biol. 95, 551-562
   Abstract »    Full Text »    PDF »
AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape.
N. J. Maness, L. E. Valentine, G. E. May, J. Reed, S. M. Piaskowski, T. Soma, J. Furlott, E. G. Rakasz, T. C. Friedrich, D. A. Price, et al. (2007)
J. Exp. Med. 204, 2505-2512
   Abstract »    Full Text »    PDF »
Cytolytic CD8+ T Cells Directed against a Cryptic Epitope Derived from a Retroviral Alternative Reading Frame Confer Disease Protection.
O. Ho and W. R. Green (2006)
J. Immunol. 176, 2470-2475
   Abstract »    Full Text »    PDF »
The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome.
E. Caron, R. Charbonneau, G. Huppe, S. Brochu, and C. Perreault (2005)
Int. Immunol. 17, 1583-1596
   Abstract »    Full Text »    PDF »
Identification of Cryptic MHC I-restricted Epitopes Encoded by HIV-1 Alternative Reading Frames.
S. Cardinaud, A. Moris, M. Fevrier, P.-S. Rohrlich, L. Weiss, P. Langlade-Demoyen, F. A. Lemonnier, O. Schwartz, and A. Habel (2004)
J. Exp. Med. 199, 1053-1063
   Abstract »    Full Text »    PDF »

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