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Science 301 (5638): 1338-1339

Copyright © 2003 by the American Association for the Advancement of Science

β-Arrestin--Not Just for G Protein-Coupled Receptors

Allen Spiegel

The beta-arrestin adaptor proteins are known to mediate the endocytosis of G protein-coupled receptors. In this way, they down-regulate the activated receptors ensuring that they are degraded or recycled within the cell. As Spiegel explains in his Perspective, it now turns out that beta-arrestins are also important for the endocytosis and down-regulation of a variety of other receptors including Frizzled 4 and TGF-beta-receptors, II and III (Chen et al., Chen et al.).

The author is at the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. E-mail: spiegela{at}

Essential role for {beta}-arrestin 2 in the regulation of Xenopus convergent extension movements.
G.-H. Kim and J.-K. Han (2007)
EMBO J. 26, 2513-2526
   Abstract »    Full Text »    PDF »
beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
I. Quack, L. C. Rump, P. Gerke, I. Walther, T. Vinke, O. Vonend, T. Grunwald, and L. Sellin (2006)
PNAS 103, 14110-14115
   Abstract »    Full Text »    PDF »
{beta}-Arrestin 1 Participates in Platelet-Activating Factor Receptor-Mediated Endocytosis of Streptococcus pneumoniae.
J. N. Radin, C. J. Orihuela, G. Murti, C. Guglielmo, P. J. Murray, and E. I. Tuomanen (2005)
Infect. Immun. 73, 7827-7835
   Abstract »    Full Text »    PDF »

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