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Science 302 (5642): 65-67

Copyright © 2003 by the American Association for the Advancement of Science

Stout Guards of the Central Nervous System

R. Mechoulam and A. H. Lichtman

Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work (Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.

R. Mechoulam is in the Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel. E-mail: mechou{at} A. H. Lichtman is in the Department of Pharmacology/Toxicology, Virginia Commonwealth University-Medical College of Virginia, Richmond, VA 23298, USA. E-mail: alichtma{at}

Selective Reduction of Cholecystokinin-Positive Basket Cell Innervation in a Model of Temporal Lobe Epilepsy.
M. S. Wyeth, N. Zhang, I. Mody, and C. R. Houser (2010)
J. Neurosci. 30, 8993-9006
   Abstract »    Full Text »    PDF »
Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus.
A. Ludanyi, L. Eross, S. Czirjak, J. Vajda, P. Halasz, M. Watanabe, M. Palkovits, Z. Magloczky, T. F. Freund, and I. Katona (2008)
J. Neurosci. 28, 2976-2990
   Abstract »    Full Text »    PDF »
Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure-Induced Ischemia in Rats.
C. Nucci, V. Gasperi, R. Tartaglione, A. Cerulli, A. Terrinoni, M. Bari, C. De Simone, A. F. Agro, L. A. Morrone, M. T. Corasaniti, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2997-3004
   Abstract »    Full Text »    PDF »
The Neuroscientist Comments.
Neuroscientist 10, 89-90
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