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Science 302 (5643): 234-235

Copyright © 2003 by the American Association for the Advancement of Science

Liver Regeneration Clocks On

Ueli Schibler

In some simple protozoans and unicellular algae, the cell cycle clock is strongly influenced by the circadian clock, such that mitotic cell division takes place only at certain times of the day. Now, as Schibler reports in his Perspective, new work on regenerating liver cells in mice (Matsuo et al.) reveals that the cell cycle clock of mammalian cells is also under the yoke of the master circadian oscillator.

The author is in the Department of Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. E-mail: ueli.schibler{at}

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L. Marpegan, T. J. Krall, and E. D. Herzog (2009)
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Light-Dependent Regulation of Cell Division in Ostreococcus: Evidence for a Major Transcriptional Input.
M. Moulager, A. Monnier, B. Jesson, R. Bouvet, J. Mosser, C. Schwartz, L. Garnier, F. Corellou, and F.-Y. Bouget (2007)
Plant Physiology 144, 1360-1369
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D. W. Bartlett and M. E. Davis (2006)
Nucleic Acids Res. 34, 322-333
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