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Science 302 (5645): 579-580

Copyright © 2003 by the American Association for the Advancement of Science

The BRCT Domain: Signaling with Friends?

Keith W. Caldecott

The tandem BRCT domains of the tumor suppressor protein BRCA1 are thought to contribute to this protein's function in the cellular response to DNA damage. In his Perspective, Caldecott discusses new work (Yu et al., Manke et al.) showing that the BRCT domains of BRCA1 and of other proteins bind specifically to phosphorylated amino acids in their protein partners.

The author is at the Genome Damage and Stability Center, University of Sussex, Brighton BN1 9RR, UK. E-mail: k.w.caldecott{at}

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1.
A. Kumagai, S.-M. Kim, and W. G. Dunphy (2004)
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   Abstract »    Full Text »    PDF »
Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences.
J. M. Stark, A. J. Pierce, J. Oh, A. Pastink, and M. Jasin (2004)
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   Abstract »    Full Text »    PDF »

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