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Science 302 (5647): 993-994

Copyright © 2003 by the American Association for the Advancement of Science

T-bet or Not T-bet

Robin D. Hatton and Casey T. Weaver

We depend on the efficiency of our adaptive immune system to combat pathogen invaders. Part of this protective response includes development of CD4 and CD8 effector T cells. As Hatton and Weaver discuss in their Perspective, key transcription factors regulating CD4 effector T cell development have been identified, whereas those governing the development of CD8 effectors have not. Hatton and Weaver describe new work showing that cooperation between two T-box transcription factors, T-bet and Eomesodermin, instigates the CD8 effector program (Pearce et al.).

The authors are in the Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Transforming Growth Factor-{beta} Protein Inversely Regulates in Vivo Differentiation of Interleukin-17 (IL-17)-producing CD4+ and CD8+ T Cells.
V. P. Dwivedi, S. Tousif, D. Bhattacharya, D. V. R. Prasad, L. Van Kaer, J. Das, and G. Das (2012)
J. Biol. Chem. 287, 2943-2947
   Abstract »    Full Text »    PDF »
T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.
E. E. Solomou, K. Keyvanfar, and N. S. Young (2006)
Blood 107, 3983-3991
   Abstract »    Full Text »    PDF »
Protective Immunity to Genital Herpes Simpex Virus Type 2 Infection Is Mediated by T-bet.
A. Svensson, I. Nordstrom, J.-B. Sun, and K. Eriksson (2005)
J. Immunol. 174, 6266-6273
   Abstract »    Full Text »    PDF »
TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids.
K. G. Tantisira, E. S. Hwang, B. A. Raby, E. S. Silverman, S. L. Lake, B. G. Richter, S. L. Peng, J. M. Drazen, L. H. Glimcher, and S. T. Weiss (2004)
PNAS 101, 18099-18104
   Abstract »    Full Text »    PDF »
Activation of Signaling Lymphocytic Activation Molecule Triggers a Signaling Cascade That Enhances Th1 Responses in Human Intracellular Infection.
M. F. Quiroga, G. J. Martinez, V. Pasquinelli, M. A. Costas, M. M. Bracco, A. Malbran, L. M. Olivares, P. A. Sieling, and V. E. Garcia (2004)
J. Immunol. 173, 4120-4129
   Abstract »    Full Text »    PDF »

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