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Science 302 (5649): 1341-1344

Copyright © 2003 by the American Association for the Advancement of Science

SPARring with Spines

Guido Meyer and Nils Brose

Synaptic plasticity underlies many essential processes in the brain, including learning and memory. In their Perspective, Meyer and Brose discuss new work (Pak and Sheng) that elucidates one possible mechanism of use-dependent synaptic plasticity in neurons. This mechanism involves the Snk kinase-induced degradation of the SPAR protein leading to alterations in the morphology of postsynaptic dendritic spines.

The authors are in the Department of Molecular Neuroscience, Max Planck Institute for Experimental Medicine, D-37075 Göttingen, Germany. E-mail: gmeyer{at}, brose{at}

Collaboration of PSD-Zip70 with Its Binding Partner, SPAR, in Dendritic Spine Maturity.
H. Maruoka, D. Konno, K. Hori, and K. Sobue (2005)
J. Neurosci. 25, 1421-1430
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