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Science 302 (5650): 1515-1516

Copyright © 2003 by the American Association for the Advancement of Science

The Paracaspase Connection

NF-kappaB is a master transcription factor that is activated by numerous different cellular pathways. In their Perspective, Yu and Lenardo discuss new work published here (Ruefli-Brasse et al.) and elsewhere that identifies MALT1/ Paracaspase as a key player in activating NF-kappaB in response to antigen receptor signaling in T and B cells.
The authors are in the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. E-mail: mlenardo{at}

Requirement for Caspase-8 in NF-{kappa}B Activation by Antigen Receptor.
H. Su, N. Bidere, L. Zheng, A. Cubre, K. Sakai, J. Dale, L. Salmena, R. Hakem, S. Straus, and M. Lenardo (2005)
Science 307, 1465-1468
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