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Science 302 (5650): 1516-1517

Copyright © 2003 by the American Association for the Advancement of Science

CELL BIOLOGY:
Eat Me or Die

John Savill, Chris Gregory, Chris Haslett

During embryonic development, the sculpting of many tissues depends on waves of apoptotic cell death among different cell populations. Unfortunately, at least in higher animals with sophisticated immune systems, dying cells must be engulfed by phagocytes to prevent a massive autoimmune response. In their Perspective, Savill et al. discuss new work (Li et al., Wang et al.) that identifies a key receptor expressed by macrophages, PSR, that is essential for cell corpse engulfment.


The authors are at the MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK. E-mail: j.savill{at}ed.ac.uk


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