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Science 302 (5650): 1516-1517

Copyright © 2003 by the American Association for the Advancement of Science

Eat Me or Die

John Savill, Chris Gregory, Chris Haslett

During embryonic development, the sculpting of many tissues depends on waves of apoptotic cell death among different cell populations. Unfortunately, at least in higher animals with sophisticated immune systems, dying cells must be engulfed by phagocytes to prevent a massive autoimmune response. In their Perspective, Savill et al. discuss new work (Li et al., Wang et al.) that identifies a key receptor expressed by macrophages, PSR, that is essential for cell corpse engulfment.

The authors are at the MRC Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh EH8 9AG, UK. E-mail: j.savill{at}

Cellular Regulation of the Inflammatory Response.
W. J. Janssen and P. M. Henson (2012)
Toxicol Pathol 40, 166-173
   Abstract »    Full Text »    PDF »
Apoptosis in the lung: induction, clearance and detection.
P. M. Henson and R. M. Tuder (2008)
Am J Physiol Lung Cell Mol Physiol 294, L601-L611
   Abstract »    Full Text »    PDF »
Engulfment of apoptotic cells by microvascular endothelial cells induces proinflammatory responses.
T. Kirsch, A. Woywodt, M. Beese, K. Wyss, J.-K. Park, U. Erdbruegger, B. Hertel, H. Haller, and M. Haubitz (2007)
Blood 109, 2854-2862
   Abstract »    Full Text »    PDF »
Inhibition of Phosphatidylserine Recognition Heightens the Immunogenicity of Irradiated Lymphoma Cells In Vivo.
A. Bondanza, V. S. Zimmermann, P. Rovere-Querini, J. Turnay, I. E. Dumitriu, C. M. Stach, R. E. Voll, U. S. Gaipl, W. Bertling, E. Poschl, et al. (2004)
J. Exp. Med. 200, 1157-1165
   Abstract »    Full Text »    PDF »

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