Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 302 (5651): 1689-1690

Copyright © 2003 by the American Association for the Advancement of Science

NEUROSCIENCE:
Microglia: The Enemy Within?

Gerd Kempermann and Harald Neumann

Unlike other brain structures, the hippocampus is able to produce new neurons throughout adult life. In their Perspective, Kempermann and Neumann discuss intriguing studies published here (Monje et al.) and elsewhere showing that inflammation induced either by irradiation or lipopolysaccharide blocks hippocampal neurogenesis, which can be alleviated by treatment with nonsteroidal anti-inflammatory drugs.


G. Kempermann is in the Neuronal Stem Cells Research Group, Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch, 13125 Berlin, Germany. E-mail: gerd.kempermann{at}mdc-berlin.de H. Neumann is in the Neuroimmunology Unit, European Neuroscience Institute Göttingen, 37073 Göttingen, Germany. E-mail: hneuman1{at}gwdg.de


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.
Y. Peng, K. Lu, Z. Li, Y. Zhao, Y. Wang, B. Hu, P. Xu, X. Shi, B. Zhou, M. Pennington, et al. (2014)
Neuro Oncology 16, 528-539
   Abstract »    Full Text »    PDF »
Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain.
M. Lalancette-Hebert, G. Gowing, A. Simard, Y. C. Weng, and J. Kriz (2007)
J. Neurosci. 27, 2596-2605
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-{alpha} Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner.
H. Takeuchi, S. Jin, J. Wang, G. Zhang, J. Kawanokuchi, R. Kuno, Y. Sonobe, T. Mizuno, and A. Suzumura (2006)
J. Biol. Chem. 281, 21362-21368
   Abstract »    Full Text »    PDF »
Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences.
R. D. Stout, C. Jiang, B. Matta, I. Tietzel, S. K. Watkins, and J. Suttles (2005)
J. Immunol. 175, 342-349
   Abstract »    Full Text »    PDF »
Neuritic Beading Induced by Activated Microglia Is an Early Feature of Neuronal Dysfunction Toward Neuronal Death by Inhibition of Mitochondrial Respiration and Axonal Transport.
H. Takeuchi, T. Mizuno, G. Zhang, J. Wang, J. Kawanokuchi, R. Kuno, and A. Suzumura (2005)
J. Biol. Chem. 280, 10444-10454
   Abstract »    Full Text »    PDF »
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
K. Takahashi, C. D.P. Rochford, and H. Neumann (2005)
J. Exp. Med. 201, 647-657
   Abstract »    Full Text »    PDF »
Functional plasticity of macrophages: reversible adaptation to changing microenvironments.
R. D. Stout and J. Suttles (2004)
J. Leukoc. Biol. 76, 509-513
   Abstract »    Full Text »    PDF »
Integrative Tumor Board: Glioblastoma Multiforme: Nutritional and Botanical Approach.
J. M. Wallace (2004)
Integr Cancer Ther 3, 152-163
   PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882