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Science 302 (5651): 1689-1690

Copyright © 2003 by the American Association for the Advancement of Science

Microglia: The Enemy Within?

Gerd Kempermann and Harald Neumann

Unlike other brain structures, the hippocampus is able to produce new neurons throughout adult life. In their Perspective, Kempermann and Neumann discuss intriguing studies published here (Monje et al.) and elsewhere showing that inflammation induced either by irradiation or lipopolysaccharide blocks hippocampal neurogenesis, which can be alleviated by treatment with nonsteroidal anti-inflammatory drugs.

G. Kempermann is in the Neuronal Stem Cells Research Group, Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch, 13125 Berlin, Germany. E-mail: gerd.kempermann{at} H. Neumann is in the Neuroimmunology Unit, European Neuroscience Institute Göttingen, 37073 Göttingen, Germany. E-mail: hneuman1{at}

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.
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