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Science 302 (5651): 1690-1691

Copyright © 2003 by the American Association for the Advancement of Science

Smurfing at the Leading Edge

Aron B. Jaffe and Alan Hall

Cell biologists are only now beginning to unravel how cells maintain their polarity and how this polarity contributes to cell migration. In their Perspective, Jaffe and Hall discuss new research (Wang et al.) describing how ubiquitination and degradation of Rho GTPase (which is an important regulator of the actin cytoskeleton) results in spatial restriction of Rho at the rear of the cell, an essential step in cellular migration.

The authors are at the MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK. E-mail: a.jaffe{at}; alan.hall{at}

A molecular switch that controls cell spreading and retraction.
P. Flevaris, A. Stojanovic, H. Gong, A. Chishti, E. Welch, and X. Du (2007)
J. Cell Biol. 179, 553-565
   Abstract »    Full Text »    PDF »
p200 RhoGAP Promotes Cell Proliferation by Mediating Cross-talk between Ras and Rho Signaling Pathways.
X. Shang, S. Y. Moon, and Y. Zheng (2007)
J. Biol. Chem. 282, 8801-8811
   Abstract »    Full Text »    PDF »
Ghrelin and the Growth Hormone Secretagogue Receptor Constitute a Novel Autocrine Pathway in Astrocytoma Motility.
V. D. Dixit, A. T. Weeraratna, H. Yang, D. Bertak, A. Cooper-Jenkins, G. J. Riggins, C. G. Eberhart, and D. D. Taub (2006)
J. Biol. Chem. 281, 16681-16690
   Abstract »    Full Text »    PDF »
CNF1-induced Ubiquitylation and Proteasome Destruction of Activated RhoA Is Impaired in Smurf1-/- Cells.
L. Boyer, L. Turchi, B. Desnues, A. Doye, G. Ponzio, J.-L. Mege, M. Yamashita, Y. E. Zhang, J. Bertoglio, G. Flatau, et al. (2006)
Mol. Biol. Cell 17, 2489-2497
   Abstract »    Full Text »    PDF »
FGF-2-Induced Wound Healing in Corneal Endothelial Cells Requires Cdc42 Activation and Rho Inactivation through the Phosphatidylinositol 3-Kinase Pathway..
J. G. Lee and E. P. Kay (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1376-1386
   Abstract »    Full Text »    PDF »
Regulation of Neurite Outgrowth in N1E-115 Cells through PDZ-Mediated Recruitment of Diacylglycerol Kinase {zeta}.
Y. Yakubchyk, H. Abramovici, J.-C. Maillet, E. Daher, C. Obagi, R. J. Parks, M. K. Topham, and S. H. Gee (2005)
Mol. Cell. Biol. 25, 7289-7302
   Abstract »    Full Text »    PDF »
Golgi polarization in a strong electric field.
J. Pu and M. Zhao (2005)
J. Cell Sci. 118, 1117-1128
   Abstract »    Full Text »    PDF »

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