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Laying down networks of neurons to form the nervous system in the developing embryo depends on numerous positional cues that direct extending axons to their target cells. In their Perspective, Imondi and Thomas discuss new work (Lyuksyutova et al.) that identifies a member of the Wnt family of signaling molecules as a crucial cue that directs commissural axons of the spinal cord to "go anterior."
The authors are at the Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037, USA. E-mail: jthomas{at}salk.edu; imondi@salk.edu
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In Science Magazine
REPORTS
Anna I. Lyuksyutova, Chin-Chun Lu, Nancy Milanesio, Leslie A. King, Nini Guo, Yanshu Wang, Jeremy Nathans, Marc Tessier-Lavigne, and Yimin Zou (12 December 2003) Science302 (5652), 1984.
[DOI: 10.1126/science.1089610] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Activation of the Wnt {beta}Catenin Pathway in a Cell Population on the Surface of the Forebrain Is Essential for the Establishment of Olfactory Axon Connections.
A. A. Zaghetto, S. Paina, S. Mantero, N. Platonova, P. Peretto, S. Bovetti, A. Puche, S. Piccolo, and G. R. Merlo (2007)
J. Neurosci.
27, 9757-9768
|Abstract »|Full Text »|PDF »
Genes That Control Ray Sensory Neuron Axon Development in the Caenorhabditis elegans Male.
