Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 302 (5653): 2078-2079

Copyright © 2003 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: ORs Rule the Roost in the Olfactory System

Joseph W. Lewcock and Randall R. Reed

It is well established that each olfactory neuron of the mammalian olfactory system expresses only one olfactory receptor (OR) out of the 1000 OR proteins encoded by the mammalian genome. In their Perspective, Lewcock and Reed discuss new findings (Serizawa et al.) that show how the OR protein itself participates in a negative feedback mechanism, which ensures that only one OR is expressed in each olfactory neuron.

The authors are in the Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis.
H. Nishizumi, K. Kumasaka, N. Inoue, A. Nakashima, and H. Sakano (2007)
PNAS 104, 20067-20072
   Abstract »    Full Text »    PDF »
Transcriptional regulation of neuronal phenotype in mammals.
Q. Ma (2006)
J. Physiol. 575, 379-387
   Abstract »    Full Text »    PDF »
Transcriptional noise and cellular heterogeneity in mammalian macrophages.
S. Ramsey, A. Ozinsky, A. Clark, K. D. Smith, P. de Atauri, V. Thorsson, D. Orrell, and H. Bolouri (2006)
Phil Trans R Soc B 361, 495-506
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882