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Science 303 (5657): 485-487

Copyright © 2004 by the American Association for the Advancement of Science

The Robin Hood of Antigen Presentation

Gennaro De Libero

Immunologists continue to unveil a startling diversity in the antigenic repertoire of T cells, which now rivals that of B cells. In his Perspective, De Libero discusses new work (Zhou et al., Moody et al.) that adds lipopeptide antigens to the list of T cell immunogens and reveals how lipid antigens are handled in antigen-presenting cells and then presented to T cells.

The author is in the Department of Research, University Hospital Basel, Basel CH-4031, Switzerland. E-mail: gennaro.delibero{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882