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Science 303 (5659): 774-775

Copyright © 2004 by the American Association for the Advancement of Science

GENETICS:
Robust Interactions

Lee Hartwell

Many of the genes controlling essential processes in cells are conserved in organisms ranging from yeast to humans. In his Perspective, Hartwell discusses how a genetic interaction network devised for yeast (Tong et al.) may contribute to understanding the complex genetics of inherited diseases in humans.

The author is in the Department of Genetics, University of Washington, Seattle, WA 98195, USA. E-mail: lhartwel{at}fhcrc.org

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Nutrigenetics in Cancer Research--Folate Metabolism and Colorectal Cancer.
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J. Nutr. 135, 2698-2702
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Combining biological networks to predict genetic interactions.
S. L. Wong, L. V. Zhang, A. H. Y. Tong, Z. Li, D. S. Goldberg, O. D. King, G. Lesage, M. Vidal, B. Andrews, H. Bussey, et al. (2004)
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The Identities of sym-2, sym-3 and sym-4, Three Genes That Are Synthetically Lethal With mec-8 in Caenorhabditis elegans.
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Evolution of Dominance in Metabolic Pathways.
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