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Science 303 (5659): 774-775

Copyright © 2004 by the American Association for the Advancement of Science

Robust Interactions

Lee Hartwell

Many of the genes controlling essential processes in cells are conserved in organisms ranging from yeast to humans. In his Perspective, Hartwell discusses how a genetic interaction network devised for yeast (Tong et al.) may contribute to understanding the complex genetics of inherited diseases in humans.

The author is in the Department of Genetics, University of Washington, Seattle, WA 98195, USA. E-mail: lhartwel{at}

Commentary: The epigenotype--a dynamic network view of development.
E. Jablonka and E. Lamm (2012)
Int. J. Epidemiol. 41, 16-20
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The Genetic Landscape of a Cell.
M. Costanzo, A. Baryshnikova, J. Bellay, Y. Kim, E. D. Spear, C. S. Sevier, H. Ding, J. L.Y. Koh, K. Toufighi, S. Mostafavi, et al. (2010)
Science 327, 425-431
   Abstract »    Full Text »    PDF »
Gene-Centric Genomewide Association Study via Entropy.
Y. Cui, G. Kang, K. Sun, M. Qian, R. Romero, and W. Fu (2008)
Genetics 179, 637-650
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Shs1 Plays Separable Roles in Septin Organization and Cytokinesis in Saccharomyces cerevisiae.
M. Iwase, J. Luo, E. Bi, and A. Toh-e (2007)
Genetics 177, 215-229
   Abstract »    Full Text »    PDF »
Inheritance Patterns of Transcript Levels in F1 Hybrid Mice.
X. Cui, J. Affourtit, K. R. Shockley, Y. Woo, and G. A. Churchill (2006)
Genetics 174, 627-637
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Diverse Functions of Spindle Assembly Checkpoint Genes in Saccharomyces cerevisiae.
J. A. Daniel, B. E. Keyes, Y. P. Y. Ng, C. O. Freeman, and D. J. Burke (2006)
Genetics 172, 53-65
   Abstract »    Full Text »    PDF »
Nutrigenetics in Cancer Research--Folate Metabolism and Colorectal Cancer.
C. M. Ulrich (2005)
J. Nutr. 135, 2698-2702
   Abstract »    Full Text »    PDF »
Combining biological networks to predict genetic interactions.
S. L. Wong, L. V. Zhang, A. H. Y. Tong, Z. Li, D. S. Goldberg, O. D. King, G. Lesage, M. Vidal, B. Andrews, H. Bussey, et al. (2004)
PNAS 101, 15682-15687
   Abstract »    Full Text »    PDF »
The Identities of sym-2, sym-3 and sym-4, Three Genes That Are Synthetically Lethal With mec-8 in Caenorhabditis elegans.
J. Yochem, L. R. Bell, and R. K. Herman (2004)
Genetics 168, 1293-1306
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Evolution of Dominance in Metabolic Pathways.
H. C. Bagheri and G. P. Wagner (2004)
Genetics 168, 1713-1735
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Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast.
S. Sarin, K. E. Ross, L. Boucher, Y. Green, M. Tyers, and O. Cohen-Fix (2004)
Genetics 168, 1763-1771
   Abstract »    Full Text »    PDF »

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