Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF- rapidly develop epithelial tumors (Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.
The authors are in the Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. E-mail: mjbissell{at}lbl.gov
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Neil A. Bhowmick, Anna Chytil, David Plieth, Agnieszka E. Gorska, Nancy Dumont, Scott Shappell, M. Kay Washington, Eric G. Neilson, and Harold L. Moses (6 February 2004) Science303 (5659), 848.
[DOI: 10.1126/science.1090922] |Abstract »|Full Text »|PDF »|Supporting Online Material »
14-3-3{sigma} associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1.
A. Ghaffari, Y. Li, R. T. Kilani, and A. Ghahary (2010)
J. Cell Sci.
123, 2996-3005
|Abstract »|Full Text »|PDF »
Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer.
H Chang, N Mohabir, S Done, and P A Hamel (2009)
J. Clin. Pathol.
62, 908-914
|Abstract »|Full Text »|PDF »
The Tumor Suppressor Functions of p27kip1 Include Control of the Mesenchymal/Amoeboid Transition.
S. Berton, B. Belletti, K. Wolf, V. Canzonieri, F. Lovat, A. Vecchione, A. Colombatti, P. Friedl, and G. Baldassarre (2009)
Mol. Cell. Biol.
29, 5031-5045
|Abstract »|Full Text »|PDF »
Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model.
J. K. Slack-Davis, E. D. Hershey, D. Theodorescu, H. F. Frierson, and J. T. Parsons (2009)
Mol. Cancer Ther.
8, 2470-2477
|Abstract »|Full Text »|PDF »
The Linear No-Threshold Relationship Is Inconsistent with Radiation Biologic and Experimental Data1.
M. Tubiana, L. E. Feinendegen, C. Yang, and J. M. Kaminski (2009)
Radiology
251, 13-22
|Full Text »|PDF »
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-{alpha} and TGF-{beta}.
C. H. Stuelten, S. D. Byfield, P. R. Arany, T. S. Karpova, W. G. Stetler-Stevenson, and A. B. Roberts (2005)
J. Cell Sci.
118, 2143-2153
|Abstract »|Full Text »|PDF »
E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs.
A. Margulis, W. Zhang, A. Alt-Holland, H. C. Crawford, N. E. Fusenig, and J. A. Garlick (2005)
Cancer Res.
65, 1783-1791
|Abstract »|Full Text »|PDF »
Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes.
M.J. BISSELL, P.A. KENNY, and D.C. RADISKY (2005)
Cold Spring Harb Symp Quant Biol
70, 343-356
|Abstract »|PDF »
rapidly develop epithelial tumors (
