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Science 303 (5659): 775-777

Copyright © 2004 by the American Association for the Advancement of Science

Respect Thy Neighbor!

Derek C. Radisky and Mina J. Bissell

The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF-beta rapidly develop epithelial tumors (Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.

The authors are in the Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. E-mail: mjbissell{at}

Beyond the Cancer Cell: Progression-Level Determinants Highlight the Multiscale Nature of Carcinogenesis Risk.
L. Hlatky and P. Hahnfeldt (2014)
Cancer Res. 74, 659-664
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14-3-3{sigma} associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1.
A. Ghaffari, Y. Li, R. T. Kilani, and A. Ghahary (2010)
J. Cell Sci. 123, 2996-3005
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Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer.
H Chang, N Mohabir, S Done, and P A Hamel (2009)
J. Clin. Pathol. 62, 908-914
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The Tumor Suppressor Functions of p27kip1 Include Control of the Mesenchymal/Amoeboid Transition.
S. Berton, B. Belletti, K. Wolf, V. Canzonieri, F. Lovat, A. Vecchione, A. Colombatti, P. Friedl, and G. Baldassarre (2009)
Mol. Cell. Biol. 29, 5031-5045
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Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model.
J. K. Slack-Davis, E. D. Hershey, D. Theodorescu, H. F. Frierson, and J. T. Parsons (2009)
Mol. Cancer Ther. 8, 2470-2477
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A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
M.-P. Wu, M.-J. Young, C.-C. Tzeng, C.-R. Tzeng, K.-F. Huang, L.-W. Wu, and C.-Y. Chou (2008)
Carcinogenesis 29, 1115-1123
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Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention.
J. T. Parsons, J. Slack-Davis, R. Tilghman, and W. G. Roberts (2008)
Clin. Cancer Res. 14, 627-632
   Abstract »    Full Text »    PDF »
Conceptual and Practical Implications of Breast Tissue Geometry: Toward a More Effective, Less Toxic Therapy.
L. Norton (2005)
Oncologist 10, 370-381
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Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-{alpha} and TGF-{beta}.
C. H. Stuelten, S. D. Byfield, P. R. Arany, T. S. Karpova, W. G. Stetler-Stevenson, and A. B. Roberts (2005)
J. Cell Sci. 118, 2143-2153
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E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs.
A. Margulis, W. Zhang, A. Alt-Holland, H. C. Crawford, N. E. Fusenig, and J. A. Garlick (2005)
Cancer Res. 65, 1783-1791
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Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes.
Cold Spring Harb Symp Quant Biol 70, 343-356
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