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Science 303 (5659): 775-777

Copyright © 2004 by the American Association for the Advancement of Science

CANCER:
Respect Thy Neighbor!

Derek C. Radisky and Mina J. Bissell

The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF-beta rapidly develop epithelial tumors (Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.


The authors are in the Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. E-mail: mjbissell{at}lbl.gov


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