Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 303 (5662): 1311-1312

Copyright © 2004 by the American Association for the Advancement of Science

HNFs--Linking the Liver and Pancreatic Islets in Diabetes

Rohit N. Kulkarni and C. Ronald Kahn

Understanding the transcriptional regulatory networks that operate in different tissues may provide some mechanistic insight into certain diseases. In their Perspective, Kulkarni and Kahn discuss new work (Odom et al.) that identifies transcriptional regulatory networks in human liver cells and islet beta cells, and highlights a defect in one transcription factor in this circuitry that may contribute to late-onset type 2 diabetes.

The authors are in the Department of Cell and Molecular Physiology, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. E-mail: rohit.kulkarni {at}

Proteomic Analysis of Native Hepatocyte Nuclear Factor-4{alpha} (HNF4{alpha}) Isoforms, Phosphorylation Status, and Interactive Cofactors.
K. Daigo, T. Kawamura, Y. Ohta, R. Ohashi, S. Katayose, T. Tanaka, H. Aburatani, M. Naito, T. Kodama, S. Ihara, et al. (2011)
J. Biol. Chem. 286, 674-686
   Abstract »    Full Text »    PDF »
Distinct Regulation of Hepatic Nuclear Factor 1{alpha} by NKX6.1 in Pancreatic Beta Cells.
W. Donelan, V. Koya, S. W. Li, and L. J. Yang (2010)
J. Biol. Chem. 285, 12181-12189
   Abstract »    Full Text »    PDF »
Structural Basis of Natural Promoter Recognition by a Unique Nuclear Receptor, HNF4{alpha}: DIABETES GENE PRODUCT.
P. Lu, G. B. Rha, M. Melikishvili, G. Wu, B. C. Adkins, M. G. Fried, and Y.-I. Chi (2008)
J. Biol. Chem. 283, 33685-33697
   Abstract »    Full Text »    PDF »
Proteomic screen defines the hepatocyte nuclear factor 1{alpha}-binding partners and identifies HMGB1 as a new cofactor of HNF1{alpha}.
M. Yu, J. Wang, W. Li, Y. Z. Yuan, C. Y. Li, X. H. Qian, W. X. Xu, Y. Q. Zhan, and X. M. Yang (2008)
Nucleic Acids Res. 36, 1209-1219
   Abstract »    Full Text »    PDF »
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
J. D. Johnson, E. Bernal-Mizrachi, E. U. Alejandro, Z. Han, T. B. Kalynyak, H. Li, J. L. Beith, J. Gross, G. L. Warnock, R. R. Townsend, et al. (2006)
PNAS 103, 19575-19580
   Abstract »    Full Text »    PDF »
Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns.
L. L. Bonnycastle, C. J. Willer, K. N. Conneely, A. U. Jackson, C. P. Burrill, R. M. Watanabe, P. S. Chines, N. Narisu, L. J. Scott, S. T. Enloe, et al. (2006)
Diabetes 55, 2534-2540
   Abstract »    Full Text »    PDF »
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient {beta}-cells.
A. M. Hennige, U. Ozcan, T. Okada, U. S. Jhala, M. Schubert, M. F. White, and R. N. Kulkarni (2005)
Am J Physiol Endocrinol Metab 289, E337-E346
   Abstract »    Full Text »    PDF »
HNF1{beta}/TCF2 mutations impair transactivation potential through altered co-regulator recruitment.
E. Barbacci, A. Chalkiadaki, C. Masdeu, C. Haumaitre, L. Lokmane, C. Loirat, S. Cloarec, I. Talianidis, C. Bellanne-Chantelot, and S. Cereghini (2004)
Hum. Mol. Genet. 13, 3139-3149
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882