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Science 303 (5666): 1983-1984

Copyright © 2004 by the American Association for the Advancement of Science

Genetic Control of Cortical Convolutions

Pasko Rakic

Development of the highly convoluted human cerebral cortex depends on the orchestrated migration of millions of cortical neurons from the brain's ventricular and subventricular zones. In a Perspective, Rakic discusses the identification of a mutation in an orphan G protein-coupled receptor that results in a congenital malformation in which overproduction of cortical neurons results in the appearance of an enlarged number of cortical convolutions (Piao et al.).

The author is in the Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA. E-mail: pasko.rakic{at}

Quantification and Discrimination of Abnormal Sulcal Patterns in Polymicrogyria.
K. Im, R. Pienaar, M. J. Paldino, N. Gaab, A. M. Galaburda, and P. E. Grant (2013)
Cereb Cortex 23, 3007-3015
   Abstract »    Full Text »    PDF »
Bilateral Posterior Periventricular Nodular Heterotopia: A Recognizable Cortical Malformation with a Spectrum of Associated Brain Abnormalities.
S. A. Mandelstam, R. J. Leventer, A. Sandow, G. McGillivray, M. van Kogelenberg, R. Guerrini, S. Robertson, S. F. Berkovic, G. D. Jackson, and I. E. Scheffer (2013)
AJNR Am. J. Neuroradiol. 34, 432-438
   Abstract »    Full Text »    PDF »
A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex.
I. Reillo, C. de Juan Romero, M. A. Garcia-Cabezas, and V. Borrell (2011)
Cereb Cortex 21, 1674-1694
   Abstract »    Full Text »    PDF »
"Where Do Auditory Hallucinations Come From?"--A Brain Morphometry Study of Schizophrenia Patients With Inner or Outer Space Hallucinations.
M. Plaze, M.-L. Paillere-Martinot, J. Penttila, D. Januel, R. de Beaurepaire, F. Bellivier, J. Andoh, A. Galinowski, T. Gallarda, E. Artiges, et al. (2011)
Schizophr Bull 37, 212-221
   Abstract »    Full Text »    PDF »
Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging.
D. J. Warren, D. J. A. Connolly, and P. D. Griffiths (2010)
AJNR Am. J. Neuroradiol. 31, 1085-1090
   Abstract »    Full Text »    PDF »
Spatial Distribution of Deep Sulcal Landmarks and Hemispherical Asymmetry on the Cortical Surface.
K. Im, H. J. Jo, J.-F. Mangin, A. C. Evans, S. I. Kim, and J.-M. Lee (2010)
Cereb Cortex 20, 602-611
   Abstract »    Full Text »    PDF »
Alterations in Midline Cortical Thickness and Gyrification Patterns Mapped in Children with 22q11.2 Deletions.
C. E. Bearden, T. G. M. van Erp, R. A. Dutton, A. D. Lee, T. J. Simon, T. D. Cannon, B. S. Emanuel, D. McDonald-McGinn, E. H. Zackai, and P. M. Thompson (2009)
Cereb Cortex 19, 115-126
   Abstract »    Full Text »    PDF »
Brain Size and Cortical Structure in the Adult Human Brain.
K. Im, J.-M. Lee, O. Lyttelton, S. H. Kim, A. C. Evans, and S. I. Kim (2008)
Cereb Cortex 18, 2181-2191
   Abstract »    Full Text »    PDF »
Primary cortical folding in the human newborn: an early marker of later functional development.
J. Dubois, M. Benders, C. Borradori-Tolsa, A. Cachia, F. Lazeyras, R. Ha-Vinh Leuchter, S. V. Sizonenko, S. K. Warfield, J. F. Mangin, and P. S. Huppi (2008)
Brain 131, 2028-2041
   Abstract »    Full Text »    PDF »
Mapping the Early Cortical Folding Process in the Preterm Newborn Brain.
J. Dubois, M. Benders, A. Cachia, F. Lazeyras, R. Ha-Vinh Leuchter, S. V. Sizonenko, C. Borradori-Tolsa, J. F. Mangin, and P. S. Huppi (2008)
Cereb Cortex 18, 1444-1454
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Deep Sulcal Landmarks Provide an Organizing Framework for Human Cortical Folding.
G. Lohmann, D. Y. von Cramon, and A. C. F. Colchester (2008)
Cereb Cortex 18, 1415-1420
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A Morphogenetic Model for the Development of Cortical Convolutions.
R. Toro and Y. Burnod (2005)
Cereb Cortex 15, 1900-1913
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Genetic Contributions to Human Gyrification: Sulcal Morphometry in Williams Syndrome.
J. S. Kippenhan, R. K. Olsen, C. B. Mervis, C. A. Morris, P. Kohn, A. Meyer-Lindenberg, and K. F. Berman (2005)
J. Neurosci. 25, 7840-7846
   Abstract »    Full Text »    PDF »
Genetics of the polymicrogyria syndromes.
A Jansen and E Andermann (2005)
J. Med. Genet. 42, 369-378
   Abstract »    Full Text »    PDF »

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