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Science 304 (5668): 223-224

Copyright © 2004 by the American Association for the Advancement of Science

Oily Barbarians Breach Ion Channel Gates

Donald W. Hilgemann

It has long been debated whether and how voltage-gated ion channels are affected by the lipid environment of the plasma membrane. In his Perspective, Hilgemann discusses new work (Oliver et al.) showing that the inactivation of voltage-gated potassium (Kv) channels can be modulated by the lipids PIP2 and arachidonic acid.

The author is in the Department of Physiology, University of Texas Southwestern, Dallas, TX 75235, USA. E-mail: donald.hilgemann{at}

Localization of the PIP2 Sensor of TRPV1 Ion Channels.
C. A. Ufret-Vincenty, R. M. Klein, L. Hua, J. Angueyra, and S. E. Gordon (2011)
J. Biol. Chem. 286, 9688-9698
   Abstract »    Full Text »    PDF »
Direct and Specific Activation of Human Inward Rectifier K+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate.
N. D'Avanzo, W. W. L. Cheng, D. A. Doyle, and C. G. Nichols (2010)
J. Biol. Chem. 285, 37129-37132
   Abstract »    Full Text »    PDF »
Cholesterol Inhibits M-type K+ Channels via Protein Kinase C-dependent Phosphorylation in Sympathetic Neurons.
S.-Y. Lee, H.-K. Choi, S.-T. Kim, S. Chung, M. K. Park, J.-H. Cho, W.-K. Ho, and H. Cho (2010)
J. Biol. Chem. 285, 10939-10950
   Abstract »    Full Text »    PDF »
Phosphatidylinositol (4,5)Bisphosphate Inhibits K+-Efflux Channel Activity in NT1 Tobacco Cultured Cells.
X. Ma, O. Shor, S. Diminshtein, L. Yu, Y. J. Im, I. Perera, A. Lomax, W. F. Boss, and N. Moran (2009)
Plant Physiology 149, 1127-1140
   Abstract »    Full Text »    PDF »
Binding and direct activation of the epithelial Na+ channel (ENaC) by phosphatidylinositides.
O. Pochynyuk, Q. Tong, A. Staruschenko, and J. D. Stockand (2007)
J. Physiol. 580, 365-372
   Abstract »    Full Text »    PDF »
Direct Modulation of Kir Channel Gating by Membrane Phosphatidylinositol 4,5-Bisphosphate.
D. Enkvetchakul, I. Jeliazkova, and C. G. Nichols (2005)
J. Biol. Chem. 280, 35785-35788
   Abstract »    Full Text »    PDF »
Frequency-dependent regulation of cardiac Na+/Ca2+ exchanger.
A. Omelchenko, R. Bouchard, S. Shurraw, M. Trac, M. Hnatowich, and L. V. Hryshko (2005)
Am J Physiol Heart Circ Physiol 289, H1594-H1603
   Abstract »    Full Text »    PDF »
The Phosphatidylinositol 3-Phosphate Phosphatase Myotubularin- Related Protein 6 (MTMR6) Is a Negative Regulator of the Ca2+-Activated K+ Channel KCa3.1.
S. Srivastava, Z. Li, L. Lin, G. Liu, K. Ko, W. A. Coetzee, and E. Y. Skolnik (2005)
Mol. Cell. Biol. 25, 3630-3638
   Abstract »    Full Text »    PDF »

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