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Science 304 (5668): 223-224

Copyright © 2004 by the American Association for the Advancement of Science

BIOCHEMISTRY:
Oily Barbarians Breach Ion Channel Gates

Donald W. Hilgemann

It has long been debated whether and how voltage-gated ion channels are affected by the lipid environment of the plasma membrane. In his Perspective, Hilgemann discusses new work (Oliver et al.) showing that the inactivation of voltage-gated potassium (Kv) channels can be modulated by the lipids PIP2 and arachidonic acid.


The author is in the Department of Physiology, University of Texas Southwestern, Dallas, TX 75235, USA. E-mail: donald.hilgemann{at}utsouthwestern.edu


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