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Science 304 (5672): 829-830

Copyright © 2004 by the American Association for the Advancement of Science

Zif and the Survival of Memory

Iván Izquierdo and Martín Cammarota

For new memories to survive, they must first undergo a time-dependent process called consolidation. When memories are retrieved, they become labile and sometimes undergo reconsolidation to retain their permanent status. In their Perspective, Izquierdo and Cammarota discuss two new studies (Lee et al., Frankland et al.) that identify the protein Zif268 as a crucial factor for memory consolidation and reconsolidation in the hippocampus and anterior cingulate cortex of rodents.

The authors are at the Centro de Memória, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600-Anexo, 90035-003 Porto Alegre, RS, Brazil. E-mail: izquier{at}

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