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Science 304 (5672): 833-834

Copyright © 2004 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: The p75 NGF Receptor Exposed

Niccoló Zampieri and Moses V. Chao

Neurotrophins such as nerve growth factor (NGF) are secreted growth factors that are important for neuronal survival and plasticity. In their Perspective, Zampieri and Chao discuss a new study (He and Garcia) that highlights some unusual features about the binding of NGF to the p75 receptor.

The authors are in the Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, New York, NY 10016, USA. E-mail: chao{at}

Importance of interaction between nerve growth factor and {alpha}9{beta}1 integrin in glial tumor angiogenesis.
E. M. Walsh, R. Kim, L. Del Valle, M. Weaver, J. Sheffield, P. Lazarovici, and C. Marcinkiewicz (2012)
Neuro Oncology 14, 890-901
   Abstract »    Full Text »    PDF »
The Rabies Virus Glycoprotein Receptor p75NTR Is Not Essential for Rabies Virus Infection.
C. Tuffereau, K. Schmidt, C. Langevin, F. Lafay, G. Dechant, and M. Koltzenburg (2007)
J. Virol. 81, 13622-13630
   Abstract »    Full Text »    PDF »
An aging pathway controls the TrkA to p75NTR receptor switch and amyloid {beta}-peptide generation.
C. Costantini, H. Scrable, and L. Puglielli (2006)
EMBO J. 25, 1997-2006
   Abstract »    Full Text »    PDF »

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