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IMMUNOLOGY: The Bell Tolls for Phagosome Maturation
Colin Watts
Phagocytosis by cells of the immune system, such as macrophages or neutrophils, is a principal host defense against invading bacteria, but is also important for the clearance of dying cells. In his Perspective, Watts discusses new work (Blander and Medzhitov) showing that activation of the Toll-like receptor signaling pathway by bacteria accelerates the maturation of phagosomes and bacterial degradation.
The author is at The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. E-mail: c.watts{at}dundee.ac.uk
The editors suggest the following Related Resources on Science sites:
Sphingosine Kinase 1 (SK1) Is Recruited to Nascent Phagosomes in Human Macrophages: Inhibition of SK1 Translocation by Mycobacterium tuberculosis.
C. R. Thompson, S. S. Iyer, N. Melrose, R. VanOosten, K. Johnson, S. M. Pitson, L. M. Obeid, and D. J. Kusner (2005)
J. Immunol.
174, 3551-3561
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