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Science 304 (5674): 1123-1124

Copyright © 2004 by the American Association for the Advancement of Science

Tickling Macrophages, a Serious Business

Stephanie Züllig and Michael O. Hengartner

Failure to remove apoptotic cells and cell debris has been linked to the development of autoimmunity. In their Perspective, Züllig and Hengartner discuss a study from Nagata and colleagues that identifies a crucial bridging protein, MFG-E8, as essential for the removal of apoptotic cells (Hanayama et al.).

The authors are at the Institute of Molecular Biology, University of Zürich, CH-8057 Zürich, Switzerland. E-mail: michael.hengartner{at}

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.
J. Kranich, N. J. Krautler, E. Heinen, M. Polymenidou, C. Bridel, A. Schildknecht, C. Huber, M. H. Kosco-Vilbois, R. Zinkernagel, G. Miele, et al. (2008)
J. Exp. Med. 205, 1293-1302
   Abstract »    Full Text »    PDF »
Integrin-dependent phagocytosis - spreading from microadhesion to new concepts.
A. G. Dupuy and E. Caron (2008)
J. Cell Sci. 121, 1773-1783
   Abstract »    Full Text »    PDF »
Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.
S. R. Stowell, S. Karmakar, C. J. Stowell, M. Dias-Baruffi, R. P. McEver, and R. D. Cummings (2007)
Blood 109, 219-227
   Abstract »    Full Text »    PDF »

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