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Science 304 (5675): 1262-1263

Copyright © 2004 by the American Association for the Advancement of Science

Nothing 'gainst Time's Scythe Can Make Defense...

Hidde L. Ploegh

Designing vaccines against viruses or tumor cells that elicit CD8 T cell responses depends on understanding how viral and tumor antigens initiate activation of na„ve CD8 T cells. In his Perspective, Ploegh explores several studies published here (Norbury et al., Wolkers et al.) and elsewhere that reveal the pathway from viral or tumor antigens to long-lived peptides that are capable of priming CD8 T cells.

The author is in the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: ploegh{at}

Targeting HIV-1 Gag into the Defective Ribosomal Product Pathway Enhances MHC Class I Antigen Presentation and CD8+ T Cell Activation.
A. Goldwich, S. S. C. Hahn, S. Schreiber, S. Meier, E. Kampgen, R. Wagner, M. B. Lutz, and U. Schubert (2008)
J. Immunol. 180, 372-382
   Abstract »    Full Text »    PDF »
Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model.
D. Tao, G. Barba-Spaeth, U. Rai, V. Nussenzweig, C. M. Rice, and R. S. Nussenzweig (2005)
J. Exp. Med. 201, 201-209
   Abstract »    Full Text »    PDF »

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