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Science 304 (5677): 1607-1609

Copyright © 2004 by the American Association for the Advancement of Science

A Linker Histone Restricts Muscle Development

Lisa Cirillo and Ken Zaret

Much chromatin research has centered on modifications to the core histones that regulate gene expression. In their Perspective, Cirillo and Zaret discuss new findings that highlight a fifth type of histone, the linker histone H1, which is now shown to work with the Msx1 homeodomain protein to regulate the differentiation of muscle progenitor cells (Lee et al.).

L. Cirillo is in the Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. K. Zaret is in the Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Histone Methyltransferase SETD3 Regulates Muscle Differentiation.
G. H. Eom, K.-B. Kim, J. H. Kim, J.-Y. Kim, J.-R. Kim, H. J. Kee, D.-W. Kim, N. Choe, H.-J. Park, H.-J. Son, et al. (2011)
J. Biol. Chem. 286, 34733-34742
   Abstract »    Full Text »    PDF »
SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.
X. Tan, J. Rotllant, H. Li, P. De Deyne, and S. J. Du (2006)
PNAS 103, 2713-2718
   Abstract »    Full Text »    PDF »

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