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Science 304 (5678): 1750-1752

Copyright © 2004 by the American Association for the Advancement of Science

Vesicular Glutamate Transporter--Shooting Blanks

Kim Schuske and Erik M. Jorgensen*

Brain activity depends on the release of the neurotransmitter glutamate by exocytosis of synaptic vesicles. In their Perspective, Schuske and Jorgensen comment on two studies (Fremeau et al., Wocjik et al.) that find that mice with the main vesicular glutamate transporter knocked out survive for several months. However, the two studies present different models for subcellular localization of the vesicular transporter and for vesicle loading.

The authors are in the Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, USA. E-mail: jorgensen{at}

Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
E. B. Malarkey and V. Parpura (2011)
J. Physiol. 589, 4271-4300
   Abstract »    Full Text »    PDF »
Vesicular Glutamate Transporter 2 Is Required for Central Respiratory Rhythm Generation But Not for Locomotor Central Pattern Generation..
A. Wallen-Mackenzie, H. Gezelius, M. Thoby-Brisson, A. Nygard, A. Enjin, F. Fujiyama, G. Fortin, and K. Kullander (2006)
J. Neurosci. 26, 12294-12307
   Abstract »    Full Text »    PDF »
Electrophysiological and gene expression profiling of neuronal cell types in mammalian neocortex.
K. Yano, T. Subkhankulova, F. J. Livesey, and H. P. C. Robinson (2006)
J. Physiol. 575, 361-365
   Abstract »    Full Text »    PDF »
Increased Expression of the Drosophila Vesicular Glutamate Transporter Leads to Excess Glutamate Release and a Compensatory Decrease in Quantal Content.
R. W. Daniels, C. A. Collins, M. V. Gelfand, J. Dant, E. S. Brooks, D. E. Krantz, and A. DiAntonio (2004)
J. Neurosci. 24, 10466-10474
   Abstract »    Full Text »    PDF »

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