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Science 305 (5685): 786-787

Copyright © 2004 by the American Association for the Advancement of Science

IMMUNOLOGY:
NK Cells Lose Their Inhibition

Peter Parham

Hepatitis C virus (HCV) infects more than 180 million people worldwide and can lead to liver failure or liver cancer later in life. As Parham discusses in his thought-provoking Perspective, a step toward understanding how the human immune system resolves HCV infection and to developing a vaccine has been made with the finding that infected individuals of a particular genotype more readily resolve HCV infection than infected individuals of other genotypes (Khakoo et al.).


The author is in the Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: peropa{at}stanford.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression.
M. R. Parkhurst, J. P. Riley, M. E. Dudley, and S. A. Rosenberg (2011)
Clin. Cancer Res. 17, 6287-6297
   Abstract »    Full Text »    PDF »
Natural killer cells and hepatitis C: action and reaction.
K. Cheent and S. I. Khakoo (2011)
Gut 60, 268-278
   Abstract »    Full Text »    PDF »
Regulatory Polymorphisms in the Interleukin-18 Promoter Are Associated with Hepatitis C Virus Clearance.
P. An, C. L. Thio, G. D. Kirk, S. Donfield, J. J. Goedert, and C. A. Winkler (2008)
The Journal of Infectious Disease 198, 1159-1165
   Abstract »    Full Text »    PDF »
A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain.
C. J. VandenBussche, S. Dakshanamurthy, P. E. Posch, and C. K. Hurley (2006)
J. Immunol. 177, 5347-5357
   Abstract »    Full Text »    PDF »
Natural Killer Receptors on CD8 T Cells and Natural Killer Cells from Different HLA-C Phenotypes in Melanoma Patients..
J. A. Campillo, J. A. Martinez-Escribano, M. R. Moya-Quiles, L. A. Marin, M. Muro, N. Guerra, A. Parrado, M. Campos, J. F. Frias, A. Minguela, et al. (2006)
Clin. Cancer Res. 12, 4822-4831
   Abstract »    Full Text »    PDF »
Killer Cell Ig-Like Receptor-Dependent Signaling by Ig-Like Transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
S. E. Kirwan and D. N. Burshtyn (2005)
J. Immunol. 175, 5006-5015
   Abstract »    Full Text »    PDF »

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