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Science 305 (5685): 786-787

Copyright © 2004 by the American Association for the Advancement of Science

NK Cells Lose Their Inhibition

Peter Parham

Hepatitis C virus (HCV) infects more than 180 million people worldwide and can lead to liver failure or liver cancer later in life. As Parham discusses in his thought-provoking Perspective, a step toward understanding how the human immune system resolves HCV infection and to developing a vaccine has been made with the finding that infected individuals of a particular genotype more readily resolve HCV infection than infected individuals of other genotypes (Khakoo et al.).

The author is in the Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: peropa{at}

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M. R. Parkhurst, J. P. Riley, M. E. Dudley, and S. A. Rosenberg (2011)
Clin. Cancer Res. 17, 6287-6297
   Abstract »    Full Text »    PDF »
Natural killer cells and hepatitis C: action and reaction.
K. Cheent and S. I. Khakoo (2011)
Gut 60, 268-278
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Regulatory Polymorphisms in the Interleukin-18 Promoter Are Associated with Hepatitis C Virus Clearance.
P. An, C. L. Thio, G. D. Kirk, S. Donfield, J. J. Goedert, and C. A. Winkler (2008)
The Journal of Infectious Disease 198, 1159-1165
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A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain.
C. J. VandenBussche, S. Dakshanamurthy, P. E. Posch, and C. K. Hurley (2006)
J. Immunol. 177, 5347-5357
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Natural Killer Receptors on CD8 T Cells and Natural Killer Cells from Different HLA-C Phenotypes in Melanoma Patients..
J. A. Campillo, J. A. Martinez-Escribano, M. R. Moya-Quiles, L. A. Marin, M. Muro, N. Guerra, A. Parrado, M. Campos, J. F. Frias, A. Minguela, et al. (2006)
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Killer Cell Ig-Like Receptor-Dependent Signaling by Ig-Like Transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
S. E. Kirwan and D. N. Burshtyn (2005)
J. Immunol. 175, 5006-5015
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