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Science 305 (5686): 954-955

Copyright © 2004 by the American Association for the Advancement of Science

NAD to the Rescue

Antonio Bedalov and Julian A. Simon

Identified 15 years ago, the Wlds mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work (Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.

A. Bedalov is in the Clinical Research Division and J. A. Simon is in the Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. E-mail: abedalov{at}, jsimon{at}

Hydrogen symbioses in evolution and disease.
A.C. Williams and D.B. Ramsden (2007)
QJM 100, 451-459
   Abstract »    Full Text »    PDF »
Subcellular Compartmentation and Differential Catalytic Properties of the Three Human Nicotinamide Mononucleotide Adenylyltransferase Isoforms.
F. Berger, C. Lau, M. Dahlmann, and M. Ziegler (2005)
J. Biol. Chem. 280, 36334-36341
   Abstract »    Full Text »    PDF »
New Treatments for Denervating Diseases.
D. Pleasure (2005)
J Child Neurol 20, 258-262
   Abstract »    PDF »

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