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Science 305 (5689): 1409-1410

Copyright © 2004 by the American Association for the Advancement of Science

Argonaute Journeys into the Heart of RISC

Erik J. Sontheimer and Richard W. Carthew

Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies (Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.

The authors are in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: erik{at}; r-carthew{at}

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