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MOLECULAR BIOLOGY: Argonaute Journeys into the Heart of RISC
Erik J. Sontheimer and Richard W. Carthew
Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies (Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.
The authors are in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: erik{at}northwestern.edu; r-carthew{at}northwestern.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
RESEARCH ARTICLES
Jidong Liu, Michelle A. Carmell, Fabiola V. Rivas, Carolyn G. Marsden, J. Michael Thomson, Ji-Joon Song, Scott M. Hammond, Leemor Joshua-Tor, and Gregory J. Hannon (3 September 2004) Science305 (5689), 1437.
[DOI: 10.1126/science.1102513] |Abstract »|Full Text »|PDF »|Supporting Online Material »
miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies.
Y.-H. Cui, L. Xiao, J. N. Rao, T. Zou, L. Liu, Y. Chen, D. J. Turner, M. Gorospe, and J.-Y. Wang (2012)
Mol. Biol. Cell
23, 151-162
|Abstract »|Full Text »|PDF »
Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.
