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Science 305 (5689): 1411-1413

Copyright © 2004 by the American Association for the Advancement of Science

Targeting Apoptotic Pathways in Cancer Cells

Catherine Denicourt and Steven F. Dowdy

A holy grail of cancer therapy has been to design peptidomimetics-small peptides containing nonnatural amino acids-that bind to target proteins and induce cancer cells to undergo apoptosis. In their Perspective, Denicourt and Dowdy discuss two new innovative strategies (Li et al., Walensky et al.) for designing peptidomimetics that target protein-protein interactions in the extrinsic and intrinsic pathways of apoptotic cell death.

The authors are in the Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0686, USA. E-mail: sdowdy{at}

Mitofusin 2 Triggers Vascular Smooth Muscle Cell Apoptosis via Mitochondrial Death Pathway.
X. Guo, K.-H. Chen, Y. Guo, H. Liao, J. Tang, and R.-P. Xiao (2007)
Circ. Res. 101, 1113-1122
   Abstract »    Full Text »    PDF »
Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress.
N. Gao, M. Rahmani, X. Shi, P. Dent, and S. Grant (2006)
Blood 107, 241-249
   Abstract »    Full Text »    PDF »
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells.
J.-Z. Qin, J. Ziffra, L. Stennett, B. Bodner, B. K. Bonish, V. Chaturvedi, F. Bennett, P. M. Pollock, J. M. Trent, M. J.C. Hendrix, et al. (2005)
Cancer Res. 65, 6282-6293
   Abstract »    Full Text »    PDF »

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