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MEDICINE: Targeting Apoptotic Pathways in Cancer Cells
Catherine Denicourt and Steven F. Dowdy
A holy grail of cancer therapy has been to design peptidomimetics-small peptides containing nonnatural amino acids-that bind to target proteins and induce cancer cells to undergo apoptosis. In their Perspective, Denicourt and Dowdy discuss two new innovative strategies (Li et al., Walensky et al.) for designing peptidomimetics that target protein-protein interactions in the extrinsic and intrinsic pathways of apoptotic cell death.
The authors are in the Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093-0686, USA. E-mail: sdowdy{at}ucsd.edu
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[DOI: 10.1126/science.1099191] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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