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Science 306 (5694): 233-234

Copyright © 2004 by the American Association for the Advancement of Science

RNAs Turn On in Tandem

Michael Famulok

The activity of many proteins is regulated allosterically such that a small molecule binding to a site distant from the active site alters the conformation of the active site and hence its activity. In his Perspective, Famulok discusses the discovery of a bacterial riboswitch composed of two RNA molecules in the untranslated region of messenger RNAs that, when both bound by glycine, allosterically regulate genes controlling glycine metabolism (Mandal et al.).

The author is at the Kekulé Institut für Organische Chemie und Biochemie, D-53121 Bonn, Germany. E-mail: m.famulok{at}

The up-regulation of ferritin expression using a small-molecule ligand to the native mRNA.
J. D. Tibodeau, P. M. Fox, P. A. Ropp, E. C. Theil, and H. H. Thorp (2006)
PNAS 103, 253-257
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