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The activity of many proteins is regulated allosterically such that a small molecule binding to a site distant from the active site alters the conformation of the active site and hence its activity. In his Perspective, Famulok discusses the discovery of a bacterial riboswitch composed of two RNA molecules in the untranslated region of messenger RNAs that, when both bound by glycine, allosterically regulate genes controlling glycine metabolism (Mandal et al.).
The author is at the Kekulé Institut für Organische Chemie und Biochemie, D-53121 Bonn, Germany. E-mail: m.famulok{at}uni-bonn.de
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In Science Magazine
REPORTS
Maumita Mandal, Mark Lee, Jeffrey E. Barrick, Zasha Weinberg, Gail Mitchell Emilsson, Walter L. Ruzzo, and Ronald R. Breaker (8 October 2004) Science306 (5694), 275.
[DOI: 10.1126/science.1100829] |Abstract »|Full Text »|PDF »|Supporting Online Material »
