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Science 306 (5695): 384-385

Copyright © 2004 by the American Association for the Advancement of Science

Withdrawal of Vioxx Casts a Shadow Over COX-2 Inhibitors

Jennifer Couzin

Will other COX-2 inhibitors suffer a fate similar to that of Vioxx, which was recently found to increase the risk of heart attacks and stroke?

Biomedical and social contributions to sustainability.
I. Wilmut, T. Wongtawan, M. Quigley, and G. Sullivan (2011)
Phil Trans R Soc A 369, 1730-1747
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Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production.
M. M. Y. Chan and A. R. Moore (2010)
J. Immunol. 184, 6418-6426
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Green Tea Protects Rats against Autoimmune Arthritis by Modulating Disease-Related Immune Events.
H. R. Kim, R. Rajaiah, Q.-L. Wu, S. R. Satpute, M. T. Tan, J. E. Simon, B. M. Berman, and K. D. Moudgil (2008)
J. Nutr. 138, 2111-2116
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Cardiovascular safety of drugs not intended for cardiovascular use: need for a new conceptual basis for assessment and approval.
J. S. Borer, H. Pouleur, E. Abadie, F. Follath, J. Wittes, M. A. Pfeffer, B. Pitt, and F. Zannad (2007)
Eur. Heart J. 28, 1904-1909
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Thromboxane A2-induced arrhythmias in the anesthetized rabbit.
M. J. Wacker, S. R. Best, L. M. Kosloski, C. J. Stachura, R. L. Smoot, C. B. Porter, and J. A. Orr (2006)
Am J Physiol Heart Circ Physiol 290, H1353-H1361
   Abstract »    Full Text »    PDF »
Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effects..
S. I. Mohammed, D. Dhawan, S. Abraham, P. W. Snyder, D. J. Waters, B. A. Craig, M. Lu, L. Wu, R. Zheng, J. Stewart, et al. (2006)
Mol. Cancer Ther. 5, 329-336
   Abstract »    Full Text »    PDF »
Informed consent - a new approach to drug regulation?.
D. J. Nutt (2006)
J Psychopharmacol 20, 3-4
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A. D. Rodrigues (2005)
Drug Metab. Dispos. 33, 1567-1575
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Cardiovascular Complications of Non-Steroidal Anti-Inflammatory Drugs.
E. Fosslien (2005)
Ann. Clin. Lab. Sci. 35, 347-385
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The Promise of Prostaglandins: Have They Fulfilled Their Potential as Therapeutic Targets for the Delay of Preterm Birth?.
D. M. Olson (2005)
Reproductive Sciences 12, 466-478
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Cyclooxygenase Inhibitor Ketorolac or Mast Cell Stabilizers: Immunologic Challenges in Cancer Therapy.
M. Khatami and J. Mulshine (2005)
Clin. Cancer Res. 11, 1350-1352
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Resolution for Sepsis?.
D. W. Gilroy and P. Vallance (2005)
Circulation 111, 2-4
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