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Science 306 (5695): 425-426

Copyright © 2004 by the American Association for the Advancement of Science

Insulin Resistance Takes a Trip Through the ER

Deborah M. Muoio and Christopher B. Newgard

Given that 80% of patients with type 2 diabetes are overweight, there must be a molecular link between obesity and diabetes. In their Perspective, Muoio and Newgard, discuss a new study (Özcan et al.) that dissects the molecular connections between signaling pathways controlling fat metabolism and insulin action. It turns out that obesity puts extra stress on the endoplasmic reticulum, which initiates a series of responses that result in blocking of the insulin signaling pathway.

The authors are in the Sarah W. Stedman Nutrition and Metabolism Center, and Departments of Pharmacology and Cancer Biology, Medicine, and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA. E-mail: newga002{at}

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