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Science 306 (5698): 983-985

Copyright © 2004 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: What Genes Tell Us About Nicotine Addiction

R. C. Hogg and D. Bertrand

The alkaloid nicotine contained in tobacco smoke is responsible for the rewarding effects of cigarette smoking and the craving associated with giving up smoking. In their Perspective, Hogg and Bertrand discuss new findings (Tapper et al.) that identify the 4 subunit of the nicotinic acetylcholine receptors expressed by neurons as a target of nicotine action.

The authors are in the Department of Neuroscience, Centre Medical Universitaire, Geneva, Switzerland. E-mail: daniel.bertrand{at}

Book Review: Acquainted with the Night: A Parent's Quest to Understand Depression and.
J. M. Valenti (2005)
Science Communication 26, 451-453
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Craving nicotine: It's in the genes.
D. Secko (2005)
Can. Med. Assoc. J. 172, 175-176
   Full Text »    PDF »

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882