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Also see the archival list of Science's Compass: Enhanced Perspectives
NEUROSCIENCE: Enhanced: What Genes Tell Us About Nicotine Addiction
R. C. Hogg and D. Bertrand
The alkaloid nicotine contained in tobacco smoke is responsible for the rewarding effects of cigarette smoking and the craving associated with giving up smoking. In their Perspective, Hogg and Bertrand discuss new findings (Tapper et al.) that identify the 4 subunit of the nicotinic acetylcholine receptors expressed by neurons as a target of nicotine action.
The authors are in the Department of Neuroscience, Centre Medical Universitaire, Geneva, Switzerland. E-mail: daniel.bertrand{at}medecine.unige.ch
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In Science Magazine
REPORTS
Andrew R. Tapper, Sheri L. McKinney, Raad Nashmi, Johannes Schwarz, Purnima Deshpande, Cesar Labarca, Paul Whiteaker, Michael J. Marks, Allan C. Collins, and Henry A. Lester (5 November 2004) Science306 (5698), 1029.
[DOI: 10.1126/science.1099420] |Abstract »|Full Text »|PDF »|Supporting Online Material »
4 subunit of the nicotinic acetylcholine receptors expressed by neurons as a target of nicotine action.
