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MEDICINE: Estrogen's Ties to COX-2 May Explain Heart Disease Gender Gap
Estrogen recruits the enzyme COX-2 in the blood vessels of mice, according to research published online by Science this week (www.sciencemag.org/cgi/content/abstract/1103333), raising the possibility that COX-2 inhibitors--including Vioxx, which was yanked off the market in September because of cardiovascular risks--might be particularly hazardous to females.
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