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MEDICINE: Estrogen's Ties to COX-2 May Explain Heart Disease Gender Gap
Jennifer Couzin
Estrogen recruits the enzyme COX-2 in the blood vessels of mice, according to research published online by Science this week (www.sciencemag.org/cgi/content/abstract/1103333), raising the possibility that COX-2 inhibitors--including Vioxx, which was yanked off the market in September because of cardiovascular risks--might be particularly hazardous to females.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Karine M. Egan, John A. Lawson, Susanne Fries, Beverley Koller, Daniel J. Rader, Emer M. Smyth, and Garret A. FitzGerald (10 December 2004) Science306 (5703), 1954.
[DOI: 10.1126/science.1103333] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Women's health and gender-based clinical trials on etoricoxib: methodological gender bias.
E. Chilet-Rosell, M. T. Ruiz-Cantero, and J. F. Horga (2009)
J. Public Health Med.
31, 434-445
|Abstract »|Full Text »|PDF »
CRHR1 Polymorphisms Predict Bone Density in Survivors of Acute Lymphoblastic Leukemia.
T. S. Jones, S. C. Kaste, W. Liu, C. Cheng, W. Yang, K. G. Tantisira, C.-H. Pui, and M. V. Relling (2008)
J. Clin. Oncol.
26, 3031-3037
|Abstract »|Full Text »|PDF »
