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Science 306 (5700): 1277-

Copyright © 2004 by the American Association for the Advancement of Science

Estrogen's Ties to COX-2 May Explain Heart Disease Gender Gap

Jennifer Couzin

Estrogen recruits the enzyme COX-2 in the blood vessels of mice, according to research published online by Science this week (, raising the possibility that COX-2 inhibitors--including Vioxx, which was yanked off the market in September because of cardiovascular risks--might be particularly hazardous to females.

Women's health and gender-based clinical trials on etoricoxib: methodological gender bias.
E. Chilet-Rosell, M. T. Ruiz-Cantero, and J. F. Horga (2009)
J Public Health 31, 434-445
   Abstract »    Full Text »    PDF »
CRHR1 Polymorphisms Predict Bone Density in Survivors of Acute Lymphoblastic Leukemia.
T. S. Jones, S. C. Kaste, W. Liu, C. Cheng, W. Yang, K. G. Tantisira, C.-H. Pui, and M. V. Relling (2008)
J. Clin. Oncol. 26, 3031-3037
   Abstract »    Full Text »    PDF »

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