Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 306 (5704): 2053-2055

Copyright © 2004 by the American Association for the Advancement of Science

Unexpected Mediators of Protein Phosphorylation

John D. York and Tony Hunter

The classic way of regulating proteins is by adding phosphate groups to them (phosphorylation), a job normally carried out by enzymes called kinases. In their Perspective, York and Hunter discuss exciting work (Saiardi et al.) suggesting that kinases are in for some stiff competition. High-energy signaling molecules called inositol pyrophosphates are able to donate phosphate groups to proteins in a nonenzymatic fashion. This represents a new way for signals to be transduced in cells.

J. D. York is in the Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA. T. Hunter is at the Molecular and Cellular Biology Laboratory, Salk Research Institute, La Jolla, CA 92037, USA. E-mail: yorkj{at}

Lipid Signaling in T-Cell Development and Function.
Y. H. Huang and K. Sauer (2010)
Cold Spring Harb Perspect Biol 2, a002428
   Abstract »    Full Text »    PDF »
The long-awaited demonstration of protein pyrophosphorylation by IP7 in vivo?.
S. Shears (2010)
PNAS 107, E17
   Full Text »    PDF »
The Nucleolus Exhibits an Osmotically Regulated Gatekeeping Activity That Controls the Spatial Dynamics and Functions of Nucleolin.
L. Yang, J. M. Reece, J. Cho, C. D. Bortner, and S. B. Shears (2008)
J. Biol. Chem. 283, 11823-11831
   Abstract »    Full Text »    PDF »
DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing.
B. Harrison, M. Kraus, L. Burch, C. Stevens, A. Craig, P. Gordon-Weeks, and T. R. Hupp (2008)
J. Biol. Chem. 283, 9999-10014
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Two Human VIP1-like Inositol Hexakisphosphate and Diphosphoinositol Pentakisphosphate Kinases.
P. C. Fridy, J. C. Otto, D. E. Dollins, and J. D. York (2007)
J. Biol. Chem. 282, 30754-30762
   Abstract »    Full Text »    PDF »
Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress.
J. H. Choi, J. Williams, J. Cho, J. R. Falck, and S. B. Shears (2007)
J. Biol. Chem. 282, 30763-30775
   Abstract »    Full Text »    PDF »
Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds.
J. Liao, D. N. Seril, A. L. Yang, G. G. Lu, and G.-Y. Yang (2007)
Carcinogenesis 28, 446-454
   Abstract »    Full Text »    PDF »
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.
J. P. Frederick, D. Mattiske, J. A. Wofford, L. C. Megosh, L. Y. Drake, S.-T. Chiou, B. L. M. Hogan, and J. D. York (2005)
PNAS 102, 8454-8459
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882