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Science 306 (5704): 2053-2055

Copyright © 2004 by the American Association for the Advancement of Science

SIGNAL TRANSDUCTION:
Unexpected Mediators of Protein Phosphorylation

John D. York and Tony Hunter

The classic way of regulating proteins is by adding phosphate groups to them (phosphorylation), a job normally carried out by enzymes called kinases. In their Perspective, York and Hunter discuss exciting work (Saiardi et al.) suggesting that kinases are in for some stiff competition. High-energy signaling molecules called inositol pyrophosphates are able to donate phosphate groups to proteins in a nonenzymatic fashion. This represents a new way for signals to be transduced in cells.


J. D. York is in the Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA. T. Hunter is at the Molecular and Cellular Biology Laboratory, Salk Research Institute, La Jolla, CA 92037, USA. E-mail: yorkj{at}duke.edu


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