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Science 306 (5705): 2202-2203

Copyright © 2004 by the American Association for the Advancement of Science

Peptide Signals Sense and Destroy Target Cells

Danielle A. Garsin

It is well established that bacteria secrete signals enabling them to communicate with other members of the same species and also with other bacterial populations. In an illuminating Perspective, Garsin discusses a cytolysin signal produced by a human pathogen, Enterococcus faecalis, that enables the bacterium to sense host target cells from afar and to ramp up production of cytolysin such that target cells are efficiently lysed (Coburn et al.).

The author is in the Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030, USA. E-mail: danielle.a.garsin{at}

Enterococcus faecalis Inhibits Hyphal Morphogenesis and Virulence of Candida albicans.
M. R. Cruz, C. E. Graham, B. C. Gagliano, M. C. Lorenz, and D. A. Garsin (2013)
Infect. Immun. 81, 189-200
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