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Science 307 (5706): 56-57

Copyright © 2005 by the American Association for the Advancement of Science

Decoding Calcium Signaling

Monte M. Winslow and Gerald R. Crabtree

Calcium ions are crucial second-messenger molecules and are particularly important during T cell development and activation. In their Perspective, Winslow and Crabtree discuss the identification of two ion channels that are key regulators of the calcium response during activation of T cells (Badou et al. and Launay et al.).

M. M. Winslow is in the Immunology Program and G. R. Crabtree is in the Departments of Pathology and Developmental Biology at the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. E-mail: crabtree{at}

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2{beta}.
X. Cai, S. Srivastava, Y. Sun, Z. Li, H. Wu, L. Zuvela-Jelaska, J. Li, R. S. Salamon, J. M. Backer, and E. Y. Skolnik (2011)
PNAS 108, 20072-20077
   Abstract »    Full Text »    PDF »
Apoptosis and Autophagy: Decoding Calcium Signals that Mediate Life or Death.
M. W. Harr and C. W. Distelhorst (2010)
Cold Spring Harb Perspect Biol 2, a005579
   Abstract »    Full Text »    PDF »
Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis.
L. Di, S. Srivastava, O. Zhdanova, Y. Ding, Z. Li, H. Wulff, M. Lafaille, and E. Y. Skolnik (2010)
PNAS 107, 1541-1546
   Abstract »    Full Text »    PDF »
The Ca2+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes.
S. A. Nicolaou, L. Neumeier, Y. Peng, D. C. Devor, and L. Conforti (2007)
Am J Physiol Cell Physiol 292, C1431-C1439
   Abstract »    Full Text »    PDF »
Phosphatidylinositol-3 Phosphatase Myotubularin-Related Protein 6 Negatively Regulates CD4 T Cells.
S. Srivastava, K. Ko, P. Choudhury, Z. Li, A. K. Johnson, V. Nadkarni, D. Unutmaz, W. A. Coetzee, and E. Y. Skolnik (2006)
Mol. Cell. Biol. 26, 5595-5602
   Abstract »    Full Text »    PDF »
Signalling during hypoxia in human T lymphocytes - critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels.
P. Szigligeti, L. Neumeier, E. Duke, C. Chougnet, K. Takimoto, S. M. Lee, A. H. Filipovich, and L. Conforti (2006)
J. Physiol. 573, 357-370
   Abstract »    Full Text »    PDF »
Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.
F. Zhong, M. C. Davis, K. S. McColl, and C. W. Distelhorst (2006)
J. Cell Biol. 172, 127-137
   Abstract »    Full Text »    PDF »

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