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Science 307 (5707): 217-218

Copyright © 2005 by the American Association for the Advancement of Science

Stat Acetylation--A Key Facet of Cytokine Signaling?

John J. O'Shea, Yuka Kanno, Xiaomin Chen, David E. Levy

Modification of proteins by addition of, for example, phosphate groups to particular amino acids in the protein is an important way to regulate the protein's activity. In their Perspective, O'Shea and colleagues discuss the intriguing finding that addition of an acetyl group to an amino acid in an important group of transcription factors called Stats might regulate their activity (Yuan et al.).

J. J. O'Shea and Y. Kanno are in the National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. X. Chen is in the Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. D. E. Levy is in the Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10016, USA.

SH2B1{beta} Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation.
Y.-J. Chang, K.-W. Chen, C.-J. Chen, M.-H. Lin, Y.-J. Sun, J.-L. Lee, I.-M. Chiu, and L. Chen (2014)
Mol. Cell. Biol. 34, 1003-1019
   Abstract »    Full Text »    PDF »
Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies.
P. Sansone and J. Bromberg (2012)
J. Clin. Oncol. 30, 1005-1014
   Abstract »    Full Text »    PDF »
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.
J. Yang, J. Huang, M. Dasgupta, N. Sears, M. Miyagi, B. Wang, M. R. Chance, X. Chen, Y. Du, Y. Wang, et al. (2010)
PNAS 107, 21499-21504
   Abstract »    Full Text »    PDF »
Epigenetic Modulation in Hematologic Malignancies: Challenges and Progress.
C. S. Mitsiades and K. C. Anderson (2009)
J Natl Compr Canc Netw 7, S-1-S-12
   Abstract »    PDF »
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
M. Pang, J. Kothapally, H. Mao, E. Tolbert, M. Ponnusamy, Y. E. Chin, and S. Zhuang (2009)
Am J Physiol Renal Physiol 297, F996-F1005
   Abstract »    Full Text »    PDF »
A phosphorylation-acetylation switch regulates STAT1 signaling.
O. H. Kramer, S. K. Knauer, G. Greiner, E. Jandt, S. Reichardt, K.-H. Guhrs, R. H. Stauber, F. D. Bohmer, and T. Heinzel (2009)
Genes & Dev. 23, 223-235
   Abstract »    Full Text »    PDF »

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